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PES1 Antibody

  • 货号：
    CSB-PA017791LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse heart tissue
      All lanes: PES1 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 69, 68 kDa
      Observed band size: 69 kDa
    • Immunofluorescent analysis of PC-3 cells using CSB-PA017791LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PES1 Polyclonal antibody
  • Uniprot No.：
    O00541
  • 基因名：
    PES1
  • 别名：
    FLJ43790 antibody; Homo sapiens pescadillo mRNA complete cds antibody; PES antibody; PES 1 antibody; pes1 antibody; PESC_HUMAN antibody; Pescadillo (zebrafish) homolog 1 containing BRCT domain antibody; Pescadillo homolog 1 antibody; Pescadillo homolog 1 containing BRCT domain (zebrafish) antibody; Pescadillo homolog antibody; Pescadillo ribosomal biogenesis factor 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Pescadillo homolog protein (378-588AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PES1 Antibody (CSB-PA017791LA01HU)，的标记方式是Non-conjugated。对于PES1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA017791LB01HU PES1 Antibody, HRP conjugated ELISA
    FITC CSB-PA017791LC01HU PES1 Antibody, FITC conjugated
    Biotin CSB-PA017791LD01HU PES1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
  • 基因功能参考文献：
    1. posttranslational modification of PES1 by SUMOylation may serve as a key factor that regulates the function of PES1 in vivo PMID: 27409667
    2. PES1 may play an important role in development of gastric cancer. PMID: 26423399
    3. PES1 may play important role in the progression of ovarian cancer by inversely regulating the ERalpha and ERbeta expression. PMID: 24376209
    4. these results uncover a potential role of PES1 in chemoresistance by regulating DNA damage response in colorectal cancer cells. PMID: 23333390
    5. Upstream of c-Jun, it was revealed that c-Jun NH2-terminal kinases (JNK) is essential for controlling PES1 expression PMID: 22860098
    6. expression of PES1 correlated positively with ERalpha expression and negatively with ERbeta expression and predicted good clinical outcome in breast cancer PMID: 22820289
    7. The physical interaction between B23 and PES1 implies that they may participate in ribosome biogenesis in a protein complex. PMID: 20011973
    8. pescadillo might play a role in promoting the proliferation and carcinogenesis of human breast cancer, and thereby might be a potential target for human breast cancer treatment. PMID: 19764998
    9. Mechanisms for the ability of Pes1 to transform cells, and its failure to immortalize them. PMID: 15273728
    10. RRB1 interacts with YPH1 (yeast pescadillo homologue 1) and other members of the Yph1 complex PMID: 15467761
    11. Pes1 and Bop1 form a stable complex with a novel member, WDR12 (PeBoW complex). PMID: 16043514
    12. Results describe the role of PeBoW-specific proteins Pes1, Bop1, and WDR12 in complex assembly and stability, nucleolar transport, and pre-ribosome association. PMID: 17353269

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  • 亚细胞定位：
    Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome.
  • 蛋白家族：
    Pescadillo family
  • 组织特异性：
    Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin.
  • 数据库链接：

    HGNC: 8848

    OMIM: 605819

    KEGG: hsa:23481

    STRING: 9606.ENSP00000346725

    UniGene: Hs.517543