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PEX26 Antibody

  • 货号：
    CSB-PA767196LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: K562 whole cell lysate
      All lanes: PEX26 antibody at 3.4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 34, 29 kDa
      Observed band size: 34 kDa
    • IHC image of CSB-PA767196LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunoprecipitating PEX26 in K562 whole cell lysate
      Lane 1: Rabbit control IgG instead of CSB-PA767196LA01HU in K562 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
      Lane 2: CSB-PA767196LA01HU (6µg) + K562 whole cell lysate (500µg)
      Lane 3: K562 whole cell lysate (20µg)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PEX26 Polyclonal antibody
  • Uniprot No.：
    Q7Z412
  • 基因名：
    PEX26
  • 别名：
    PEX26 antibody; Peroxisome assembly protein 26 antibody; Peroxin-26 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Peroxisome assembly protein 26 protein (1-159AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PEX26 Antibody (CSB-PA767196LA01HU)，的标记方式是Non-conjugated。对于PEX26 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA767196LB01HU PEX26 Antibody, HRP conjugated ELISA
    FITC CSB-PA767196LC01HU PEX26 Antibody, FITC conjugated
    Biotin CSB-PA767196LD01HU PEX26 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence.
  • 基因功能参考文献：
    1. In yeast, PEX26 follows the pathway that also ensures correct targeting of Pex15: PEX26 enters the endoplasmic reticulum (ER) in a GET-dependent and Pex19-independent manner. PMID: 26627908
    2. results suggested that peroxisome biogenesis requires Pex1p- and Pex6p-regulated dissociation of Pex14p from Pex26p PMID: 25016021
    3. PEX19 formed a complex with the peroxisomal tail anchored protein PEX26 in the cytosol and translocated it directly to peroxisomes by a TRC40-independent class I pathway. PMID: 23460677
    4. degree of temperature sensitivity in pex26 cell lines is predictive of the clinical phenotype in patients with PEX26 deficiency PMID: 12851857
    5. PEX26 deficiency impairs peroxisomal import of both PTS1- and PTS2-targeted matrix proteins. It undergoes alternative splicing to produce several splice forms, including PEX26-delta, which rescues peroxisome biogenesis in PEX26-deficient cells. PMID: 15858711
    6. Pex26p functions in recruiting to peroxisomes the complexes of the AAA ATPase peroxins. PMID: 16257970
    7. We analyzed targeting of human PEX26. Its C-terminal-targeting signal contains two binding sites for PEX19 and we conclude C-terminal PEX19-binding sites mark tail-anchored proteins for delivery to peroxisomes. PMID: 16763195
    8. the relative fraction of disease-causing alleles that occur in the coding and splice junction sequences of PEX26 gene. PMID: 19105186

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  • 相关疾病：
    Peroxisome biogenesis disorder complementation group 8 (PBD-CG8); Peroxisome biogenesis disorder 7A (PBD7A); Peroxisome biogenesis disorder 7B (PBD7B)
  • 亚细胞定位：
    Peroxisome membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Peroxin-26 family
  • 组织特异性：
    Widely expressed. Highly expressed in kidney, liver, brain and skeletal muscles. Expressed at intermediate level in pancreas, placenta and heart. Weakly expressed in lung.
  • 数据库链接：

    HGNC: 22965

    OMIM: 608666

    KEGG: hsa:55670

    STRING: 9606.ENSP00000331106

    UniGene: Hs.517400