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PHF21A Antibody

  • 货号：
    CSB-PA017911LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse liver tissue, Mouse kidney tissue
      All lanes: PHF21A antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 75, 71 kDa
      Observed band size: 75 kDa
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA017911LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA017911LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA017911LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PHF21A Polyclonal antibody
  • Uniprot No.：
    Q96BD5
  • 基因名：
    PHF21A
  • 别名：
    BHC80a antibody; BM-006 antibody; BRAF35-HDAC complex protein BHC80 antibody; BRAF35/HDAC2 complex (80 kDa) antibody; KIAA1696 antibody; PF21A_HUMAN antibody; PHD finger protein 21A antibody; PHF21A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human PHD finger protein 21A protein (312-487AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PHF21A Antibody (CSB-PA017911LA01HU)，的标记方式是Non-conjugated。对于PHF21A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA017911LB01HU PHF21A Antibody, HRP conjugated ELISA
    FITC CSB-PA017911LC01HU PHF21A Antibody, FITC conjugated
    Biotin CSB-PA017911LD01HU PHF21A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.
  • 基因功能参考文献：
    1. this case lends further support that haploinsufficiency of PHF21A contributes to the intellectual disability and craniofacial abnormalities in PSS and that there are other genes in the region which likely contribute to the behavioral phenotype in this syndrome. PMID: 28127865
    2. we have uncovered evidence that the ID and CFA phenotypes are both caused by haploinsufficiency of a single gene, PHF21A, at 11p11.2. PMID: 22770980
    3. Presumably serves as a scaffold protein in BHC in neuronal as well as non-neuronal cells. Possible role in spermatogenesis. PMID: 15325272
    4. the recovery of neurosecretion depends on the reciprocal level of BHC80 and REST, with BHC80 working as a negative modulator of REST repression PMID: 19439607
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Highly expressed in brain. Expressed at lower level in other tissues, including heart, kidney, liver, lung and skeletal muscle. Abundantly expressed in fetal brain.
  • 数据库链接：

    HGNC: 24156

    OMIM: 608325

    KEGG: hsa:51317

    STRING: 9606.ENSP00000398824

    UniGene: Hs.502458