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PHF5A Antibody

  • 货号：
    CSB-PA017915EA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA017915EA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA017915EA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA017915EA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PHF5A Polyclonal antibody
  • Uniprot No.：
    Q7RTV0
  • 基因名：
    PHF5A
  • 别名：
    1110007B08Rik antibody; Ac2 246 antibody; bK223H9.2 antibody; INI antibody; MGC1346 antibody; OTTHUMP00000198827 antibody; PHD finger 5a antibody; PHD finger like domain containing protein 5A antibody; PHD finger like domain protein 5A antibody; PHD finger protein 5A antibody; PHD finger-like domain protein 5A antibody; PHD finger-like domain-containing protein 5A antibody; Phf5a antibody; PHF5A_HUMAN antibody; Rds3 antibody; SAP14b antibody; SF3b14b antibody; Splicing factor 3B associated 14 kDa protein antibody; Splicing factor 3B-associated 14 kDa protein antibody; Transcription factor INI antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human PHD finger-like domain-containing protein 5A protein (1-110AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PHF5A Antibody (CSB-PA017915EA01HU)，的标记方式是Non-conjugated。对于PHF5A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA017915EB01HU PHF5A Antibody, HRP conjugated ELISA
    FITC CSB-PA017915EC01HU PHF5A Antibody, FITC conjugated
    Biotin CSB-PA017915ED01HU PHF5A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3), on PAF1C targets, self-renewal and pluripotency genes. Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes, and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies. Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation. Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha.
  • 基因功能参考文献：
    1. PHF5A-SF3B1 forms a central node for binding to splicing modulators PMID: 28541300
    2. We found PHF5A, a component of the U2 snRNP mRNA splicing factor, blocks expression from recombinant Adeno-associated virus vectors PMID: 26244496
    3. PHF5A facilitates recognition of exons with unusual C-rich 3' splice sites in thousands of essential genes PMID: 23651857
    4. The molecular and genetic research in this paper is performed on mouse but the paper identifies and discusses homologues found in human genomic sequence databases. PMID: 12054543
  • 亚细胞定位：
    Nucleus. Nucleus speckle.
  • 蛋白家族：
    PHF5 family
  • 数据库链接：

    HGNC: 18000

    OMIM: 617846

    KEGG: hsa:84844

    STRING: 9606.ENSP00000216252

    UniGene: Hs.474980