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PHKA1 Antibody

  • 货号：
    CSB-PA695381
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA695381(PHKA1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: CSB-PA695381(PHKA1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

产品详情

  • Uniprot No.：
    P46020
  • 基因名：
  • 别名：
    5330411D17 antibody; 9830108K24Rik antibody; kinase PHKA1 antibody; KPB1 antibody; KPB1_HUMAN antibody; MGC132604 antibody; Pcyt1b antibody; PHKA antibody; PHKA1 antibody; Phosphorylase b kinase regulatory subunit alpha antibody; Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform antibody; Phosphorylase kinase alpha M subunit antibody; phosphorylase kinase, alpha 1 (muscle) antibody; RP23 210E20.1 antibody; skeletal muscle isoform antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Rat
  • 免疫原：
    Synthetic peptide of Human PHKA1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
  • 基因功能参考文献：
    1. muscle PHKA deficiency may present as an almost asymptomatic condition, despite a mild impairment of muscle PMID: 22238410
    2. alpha- and beta-subunits possess amino-terminal glucoamylase-like domains and suggests that they might possess a previously overlooked amylase activity PMID: 12876330
    3. X-linked PHK deficiency causes a mild metabolic myopathy with blunted muscle glycogen breakdown and impaired lactate production during dynamic exercise, which impairs oxidative capacity only marginally PMID: 18401027
  • 相关疾病：
    Glycogen storage disease 9D (GSD9D)
  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Phosphorylase b kinase regulatory chain family
  • 组织特异性：
    Muscle specific. Isoform 1 is predominant in vastus lateralis muscle. Isoform 2 predominates slightly in heart, and it predominates clearly in the other tissues tested.
  • 数据库链接：

    HGNC: 8925

    OMIM: 300559

    KEGG: hsa:5255

    STRING: 9606.ENSP00000362643

    UniGene: Hs.201379