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PHLDA3 Antibody

  • 货号：
    CSB-PA017932LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver using CSB-PA017932LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PHLDA3 Polyclonal antibody
  • Uniprot No.：
    Q9Y5J5
  • 基因名：
    PHLDA3
  • 别名：
    PHLA3_HUMAN antibody; PHLDA 3 antibody; phlda3 antibody; Pleckstrin homology like domain family A member 2 antibody; Pleckstrin homology like domain family A member 3 antibody; Pleckstrin homology-like domain family A member 3 antibody; TDAG51/Ipl homolog 1 antibody; TDAG51/Ipl homologue 1 antibody; TIH 1 antibody; TIH1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Pleckstrin homology-like domain family A member 3 protein (43-95AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PHLDA3 Antibody (CSB-PA017932LA01HU)，的标记方式是Non-conjugated。对于PHLDA3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA017932LB01HU PHLDA3 Antibody, HRP conjugated ELISA
    FITC CSB-PA017932LC01HU PHLDA3 Antibody, FITC conjugated
    Biotin CSB-PA017932LD01HU PHLDA3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.
  • 基因功能参考文献：
    1. although iPSCs and ESCs share lots of common features, we did not find that PHLDA3 is important to ES cell differentiation. PMID: 28588267
    2. Low PHLDA3 expression in ESCC may be predictive of tumor recurrence suggesting that Akt activation may be a therapeutic target in ESCCs PMID: 25667479
    3. Results indicate that tumor suppressor PHLDA3-mediated pathway is important in the development of pancreatic neuroendocrine tumors (PanNETs). PMID: 24912192
    4. findings indicate somatic mutation of PHLDA3 is rare in common cancer types; PHLDA3 expression was lost in 22% of prostate cancers; these results indicate that PHLDA3 are altered in prostate cancers by loss of expression PMID: 21753719
    5. Study identifies PHLDA3 as a p53 target gene that encodes a PH domain-only protein and finds that PHLDA3 competes with the PH domain of Akt for binding of membrane lipids, inhibiting Akt translocation to the cellular membrane and activation. PMID: 19203586

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  • 亚细胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    PHLDA3 family
  • 组织特异性：
    Widely expressed with lowest expression in liver and spleen.
  • 数据库链接：

    HGNC: 8934

    OMIM: 607054

    KEGG: hsa:23612

    STRING: 9606.ENSP00000356278

    UniGene: Hs.153944