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PI4K2B Antibody

  • 货号：
    CSB-PA017954GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8TCG2
  • 基因名：
  • 别名：
    2610042N09Rik antibody; 4933409G22Rik antibody; FLJ11105 antibody; P4K2B_HUMAN antibody; Phosphatidylinositol 4 kinase type 2 beta antibody; Phosphatidylinositol 4 kinase type II beta antibody; Phosphatidylinositol 4-kinase type 2-beta antibody; Phosphatidylinositol 4-kinase type II-beta antibody; PI4K 2 beta antibody; PI4K 2b antibody; PI4K II beta antibody; PI4K IIb antibody; Pi4k2b antibody; PI4KII-BETA antibody; PI4KIIb antibody; PIK42B antibody; Type II phosphatidylinositol 4 kinase beta isoform antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PI4K2B
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.
  • 基因功能参考文献：
    1. RNA interference of the type II phosphatidylinositol 4-kinases PI4KIIa and PI4KIIa in primary human endothelial cells leads to formation of an increased proportion of short WPB with perturbed packing of VWF, as exemplified by increased exposure of antibody-binding sites. PMID: 27068535
    2. Here two crystal structures are presented: the structure of human PIK42A and the structure of PIK42B containing a nucleoside analogue. PMID: 26143926
    3. Results provide evidence that type II PtdIns 4-kinase b was indeed recruited to CD4- p56lck complex upon CD4 receptor cross linking, suggests a mechanism for its association and a role for it in CD4-mediated intracellular calcium release. PMID: 24972704
    4. Canonical tyrosine residues mutation in FcepsilonRIgamma ITAM (Y65 and Y76) reveals that these two tyrosine residues in gamma subunit are required for its interaction with type II PtdIns 4-kinases. PMID: 24481753
    5. type II PtdIns 4-kinase beta is a key component in early T cell activation signaling cascades PMID: 23619705
    6. PIP4Kbeta interacts with and modulates nuclear localization of the PIP4Kalpha. PMID: 20583997
    7. There is no evidence to suggest that PI4K2B is contributing to bipolar disorder in this family but a role for this gene in schizophrenia has not been excluded. PMID: 19539307
    8. Type II PtdIns 4-kinase beta interacts with TCR-CD3 zeta chain. The C-terminal ITAM is critical for enzyme docking on the zeta chain. The association is tyrosyl phosphorylation dependent. Mutation of Y-151 & Y-142 disrupts interaction of the 2 proteins. PMID: 16337488
    9. UV irradiation increases nuclear PtdIns5P levels via inhibition of the activity of the beta isoform of PtdIns5P 4-kinase (PIP4Kbeta), an enzyme that can phosphorylate and remove PtdIns5P. PMID: 16949365
    10. LB-PI4K2B-1S-specific CD4(+) T cells contributed to the antitumor response by both directly eliminating malignant cells as effector cells and stimulating CD8(+) T cell immunity as helper cells. PMID: 18316730

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  • 亚细胞定位：
    Cytoplasm. Membrane. Note=Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac-GTP-dependent mechanism.
  • 蛋白家族：
    PI3/PI4-kinase family, Type II PI4K subfamily
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 18215

    OMIM: 612101

    KEGG: hsa:55300

    STRING: 9606.ENSP00000264864

    UniGene: Hs.191701