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PITPNM1 Antibody

  • 货号：
    CSB-PA121814
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA121814(PITPNM1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA121814(PITPNM1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    O00562
  • 基因名：
    PITPNM1
  • 别名：
    DRES9 antibody; Drosophila retinal degeneration B antibody; Drosophila retinal degeneration B homolog antibody; FLJ44997 antibody; membrane-associated 1 antibody; Membrane-associated phosphatidylinositol transfer protein 1 antibody; NIR 2 antibody; NIR-2 antibody; NIR2 antibody; OTTHUMP00000236414 antibody; OTTHUMP00000236415 antibody; Phosphatidylinositol transfer protein antibody; phosphatidylinositol transfer protein membrane associated antibody; PITM1_HUMAN antibody; PITPnm 1 antibody; PITPNM antibody; Pitpnm1 antibody; PYK2 N terminal domain interacting receptor 2 antibody; Pyk2 N-terminal domain-interacting receptor 2 antibody; RD 9 antibody; RD9 antibody; RDGB antibody; RDGB1 antibody; RDGBA1 antibody; retinal degeneration B alpha 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human PITPNM1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the transfer of phosphatidylinositol (PI) between membranes. Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC. Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions.
  • 基因功能参考文献：
    1. results suggest that Nir2 not only enhances EMT in vitro and breast cancer metastasis in animal models, but also contributes to breast cancer progression in human patients. PMID: 25179602
    2. Phosphatidic acid production triggers Phosphatidylinositol 4,5-Bisphosphate replenishment mediated by Nir2 and Nir3 at endoplasmic reticulum-plasma membrane junctions. PMID: 25887399
    3. Nir2 translocates from the Golgi complex to the plasma membrane in response to GF stimulation. PMID: 23897088
    4. Results suggest a feedback mechanism that replenishes PM PIP2 during receptor-induced Ca(2+) signaling via the Ca(2+) effector E-Syt1 and the PITP Nir2 at ER-PM junctions. PMID: 24183667
    5. Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis. PMID: 12077336
    6. A specific Thr residue in the Nir2 PI-transfer domain provides a regulatory site for targeting to lipid droplets. This may affect intracellular lipid trafficking & distribution & explain the dominant effect of the RdgB-T59E mutant on retinal degeneration. PMID: 12225667
    7. Phosphorylation of Nir2 by Cdk1 facilitates its dissociation from the Golgi apparatus, and phospho-Nir2 is localized in the cleavage furrow and midbody during cytokinesis. PMID: 15125835
    8. Nir2 is involved in maintaining a critical DAG pool in the Golgi apparatus by regulating its consumption via the CDP-choline pathway PMID: 15723057
    9. RdgB homologs play a preemptive role in excluding endogenous and exogenous modified purine deoxyribonucleoside triphosphates (dTNPs) from incorporation into DNA. PMID: 17090528

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  • 亚细胞定位：
    Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Lipid droplet. Cleavage furrow. Midbody.
  • 蛋白家族：
    PtdIns transfer protein family, PI transfer class IIA subfamily
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 9003

    OMIM: 608794

    KEGG: hsa:9600

    STRING: 9606.ENSP00000348772

    UniGene: Hs.372295