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PJA1 Antibody

  • 货号：
    CSB-PA018049GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8NG27
  • 基因名：
    PJA1
  • 别名：
    E3 ubiquitin-protein ligase Praja 1 antibody; E3 ubiquitin-protein ligase Praja-1 antibody; PJA1 antibody; PJA1_HUMAN antibody; PRAJA 1 antibody; Praja ring finger 1 antibody; Praja1 antibody; RING finger protein 70 antibody; RNF 70 antibody; RP23-414J22.4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PJA1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome. May be involved in protein sorting.
  • 基因功能参考文献：
    1. Data provide clues into novel aspects of Praja1 function. PMID: 21461837
    2. these results suggest a role for PRAJA1 in regulating the level of PRC2 by targeting its free subunits for Ub-mediated proteasomal degradation. PMID: 21513699
    3. A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1. PMID: 11959851
    4. Involved in protein ubiquitination in the brain. Candidate gene for X-linked mental retardation. PMID: 12036302
  • 组织特异性：
    Expressed in various regions of the brain including the cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Highest levels in the cerebral cortex.
  • 数据库链接：

    HGNC: 16648

    OMIM: 300420

    KEGG: hsa:64219

    STRING: 9606.ENSP00000355014

    UniGene: Hs.522679