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PKD2L1 Antibody

  • 货号：
    CSB-PA214505
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA214505(PKD2L1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9P0L9
  • 基因名：
    PKD2L1
  • 别名：
    B830002B15 antibody; BC046386 antibody; PCL antibody; PK2L1 antibody; PK2L1_HUMAN antibody; PKD2L antibody; PKD2L1 antibody; PKDL antibody; Polycystic kidney disease 2 like 1 antibody; Polycystic kidney disease 2 like 1 protein antibody; Polycystic kidney disease 2-like 1 protein antibody; Polycystin L antibody; Polycystin-2 homolog antibody; Polycystin-2L1 antibody; Polycystin-L antibody; Polycystin-L1 antibody; Transient receptor potential cation channel subfamily P member 3 antibody; TRPP3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human PKD2L1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration. The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription. Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells. The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again. May play a role in the perception of carbonation taste. May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH.
  • 基因功能参考文献：
    1. The pore helix and transmembrane segment 6 of PKD2L1 are involved in upper and lower-gate opening, adopt an open conformation. PMID: 29567962
    2. PKD2 and PKD1 genes are mutated in autosomal dominant polycystic kidney disease. PKD2 can form either a homomeric cation channel or a heteromeric complex with the PKD1 receptor, presumed to respond to ligand(s) and/or mechanical stimuli. Here, we identify a two-residue hydrophobic gate in PKD2L1, and a single-residue hydrophobic gate in PKD2. PMID: 29899465
    3. palmitoylation at Cys-38 and phosphorylation at Thr-39 independently regulated TRPP3 channel function PMID: 27754867
    4. our study identified C1 as the first PKD2L1 domain essential for both PKD2L1 trimerization and channel function, and suggest that PKD2L1 and PKD2L1/PKD1L3 channels share the PKD2L1 trimerization process. PMID: 25820328
    5. Trimerization may be important for both homo- and possibly heteromeric assemblies of PKD2L1. PMID: 22193359
    6. This study demonistrated that human PKD2L play the role of food preference behavior. PMID: 22794107
    7. Pkd2L1 is a novel target channel whose function is regulated by the versatile scaffolding protein RACK1. PMID: 22174419
    8. Despite the moderate sequence identity between C-terminal regulatory domains (CRDs) of PKD2 and PKD2L1, they both form trimers, implying that trimeric organization of CRDs may be true of all polycystin channels. PMID: 20408813
    9. the PKD2L1-PKD1L3 complex is involved in acid sensing in vivo PMID: 20406802
    10. The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation. PMID: 11959145
    11. Taken together, alpha-actinin not only attaches TRPP3 to the cytoskeleton but also up-regulates TRPP3 channel function. PMID: 17944866

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  • 亚细胞定位：
    Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle.
  • 蛋白家族：
    Polycystin family
  • 组织特异性：
    Detected in taste bud cells in fungiform papillae (at protein level). Ubiquitous. Expressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver. Isoform 4 appears to be expressed only in transformed lymphoblasts.
  • 数据库链接：

    HGNC: 9011

    OMIM: 604532

    KEGG: hsa:9033

    STRING: 9606.ENSP00000325296

    UniGene: Hs.159241