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PKP4 Antibody

  • 货号：
    CSB-PA040222
  • 规格：
    ￥880
  • 图片：
    • Western blot analysis of mouse-heart lysis using Plakophilin 4 antibody.
  • 其他：

产品详情

  • Uniprot No.：
    Q99569
  • 基因名：
    PKP4
  • 别名：
    Catenin 4 antibody; Catenin4 antibody; FLJ31261 antibody; FLJ42243 antibody; p0071 antibody; PKP 4 antibody; PKP4 antibody; PKP4_HUMAN antibody; Plakophilin 4 antibody; Plakophilin-4 antibody; Plakophilin4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Plakophilin 4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.
  • 基因功能参考文献：
    1. p0071 is required for directional vesicle movement and secretion of different KIF3-transported carriers, thereby regulating the transport of intracellular membrane vesicles along microtubules. PMID: 28808088
    2. Data show that patients with both abnormal expression of p0071 and E-cadherin had a statistically significant shorter survival than the patients without both abnormal expression. PMID: 28898462
    3. p0071 has a key role in regulating recycling through the Rab11a-dependent perinuclear recycling compartment. PMID: 24163434
    4. This review article focuses on the functions of the p0071 protein and its closest relatives in regulating cell adhesion and cytoskeletal organization, which are critically involved in the control of cell polarity. [review] PMID: 23640939
    5. Findings suggest that aspects of folliculin tumour suppressor function are linked to interaction with p0071 and the regulation of RhoA signalling. PMID: 22965878
    6. These data support a model in which dysregulation of the FLCN-p0071 interaction leads to alterations in cell adhesion, cell polarity, and RhoA signaling. PMID: 23139756
    7. The structural and functional roles of p0071 are suggested by its preferential occurrence in distinct tubule segments, and its potential use as a cytodiagnostic cell type marker in renal pathology is discussed. PMID: 19830446
    8. ERBIN interacts in vivo with p0071 and that it may be involved in the organization of adherens junctions and the desmosomes of epithelia PMID: 12047349
    9. In addition to plakoglobin, p0071 is the second armadillo protein present in both types of adhesive junctions and may play a role in regulating crosstalk between adherens junctions and desmosomes. PMID: 12615965
    10. p0071 bound to the first 160 amino-terminal residues of desmoplakin and also interacted directly with plakoglobin, suggesting that p0071 may regulate desmosome assembly by controlling plakoglobin availability PMID: 15304078
    11. These findings support an essential role for p0071 in spatially regulating restricted Rho signalling during cytokinesis. PMID: 17115030
    12. In this review p0071 catenin, a close relative of p120 catenin, associates and regulates RhoA-GTPase at the cleavage furrow during cytokinesis. PMID: 17264675
    13. Protein p0071 has been localized as a plaque protein in adhaerens junctions of diverse epithelia and certain vascular endothelia. PMID: 19005682
    14. Data indicate that p0071 and Ect2 are transported via distinct motors and identify a novel pathway implicating KIF3 in the regulation of actin organization during cytokinesis. PMID: 19339549

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  • 亚细胞定位：
    Cell junction, desmosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell membrane; Peripheral membrane protein. Note=Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells.
  • 蛋白家族：
    Beta-catenin family
  • 数据库链接：

    HGNC: 9026

    OMIM: 604276

    KEGG: hsa:8502

    STRING: 9606.ENSP00000374409

    UniGene: Hs.407580