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PLA2G4C Antibody

  • 货号：
    CSB-PA070099
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9UP65
  • 基因名：
  • 别名：
    cPLA2 gamma antibody; Cytosolic phospholipase A2 gamma antibody; EC 3.1.1.4 antibody; PA24C_HUMAN antibody; Phospholipase A2 group IVC antibody; PLA2G4C antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human cPLA2-γ.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calcium-independent phospholipase, lysophospholipase and O-acyltransferase involved in phospholipid remodeling with implications in endoplasmic reticulum membrane homeostasis and lipid droplet biogenesis. Preferentially hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids with choline and ethanolamine head groups, producing lysophospholipids that are used in deacylation-reacylation cycles. Transfers the sn-1 fatty acyl from one lysophospholipid molecule to the sn-2 position of another lysophospholipid to form diacyl, alkylacyl and alkenylacyl glycerophospholipids. Cleaves ester bonds but not alkyl or alkenyl ether bonds at sn-1 position of lysophospholipids. Catalyzes sn-2 fatty acyl transfer from phospholipids to the sn-2 position of 1-O-alkyl or 1-O-alkenyl lysophospholipids with lower efficiency. In response to dietary fatty acids, may play a role in the formation of nascent lipid droplets from the endoplasmic reticulum likely by regulating the phospholipid composition of these organelles.; (Microbial infection) May play a role in replication and assembly of human hepatitis C virus (HCV). In response to HCV infection, promotes remodeling of host endoplasmic reticulum membranes to form organelle-like structures called membranous web, where HCV replication occur. Can further mediate translocation of replication complexes to lipid droplets to enable virion assembly.; (Microbial infection) May facilitate human T-lymphotropic virus type 1 (HTLV-1) infection by promoting leukotriene B4 (LTB4) biosynthesis. LTB4 acts as a chemoattractant for HTLV-1-infected CD4-positive T cells and favors cell to cell viral transmission.
  • 基因功能参考文献：
    1. Five single-nucleotide polymorphisms (SNPs) (rs9226, rs1045376, rs251684, rs2307279, and rs156631) in PLA2G4C and four SNPs (rs6533451, rs2285714, rs2285713, and rs11728699) in PLA2G12A were selected and genotyped. Our results showed a significant association between ASD and the rs251684 variant of PLA2G4C. The rs251684 polymorphism of PLA2G4C may be associated with Autism Spectrum Disorder risk. PMID: 27611910
    2. The A allele in PLA2G4C single nucleotide polymorphism (rs1549637) is associated with a worse prognosis in patients with colorectal cancer, especially in stage II. PMID: 26364726
    3. site-specific cytosine methylation of the CpT of PLA2G4C may play a role in the pathogenesis of schizophrenia. PMID: 22878031
    4. These findings suggest that IVC-PLA(2) is involved in regulations of macrophage differentiation and macrophage polarization. PMID: 22108055
    5. these results suggest that cPLA(2)gamma plays an important role in cancer cell chemotaxis. PMID: 21600875
    6. Findings suggest that variation in PLA2G4C may influence preterm birth risk by increasing levels of prostaglandins, which are known to regulate labor. PMID: 21184677
    7. cPLA(2) has a role in the induction of cell autonomous cellular immunity to Chlamydia PMID: 20452986
    8. locus showed a weak association with schizophrenia in a Chinese population PMID: 20016400
    9. Novel PLA2G4C polymorphism as a molecular diagnostic A minisatellite polymorphism in the untranslated region of exon 1, with allelic variants that have one, two or three 27-bp repeats PMID: 11958371
    10. enzymatic properties PMID: 12039969
    11. TNF-alpha & IFN-gamma induce gene expression of a novel cytosolic PLA(2) IVC in human airway epithelial cells. The possibility that it is involved in cytokine-mediated inflammation in the respiratory tract is inferred. PMID: 12396716
    12. Down-regulation of Phospholipase A2 is associated with colon tumorigenesis PMID: 15788676
    13. identification of its remarkable substrate selectivity that results in the highly selective generation of 2-arachidonoyl lysophosphatidylcholine PMID: 15908428
    14. results indicate that complete C-terminal processing is important for the functional expression of cPLA2, although not for its membrane localization PMID: 15944408
    15. Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells PMID: 16882668
    16. iPLA2gamma has roles in the lipid plasticity of myocardium, in generating signaling metabolites, and in modulating energy storage and utilization in myocardium in different metabolic contexts PMID: 17213206
    17. Single nucleotide polymorphism is asociated with schizzophrenia in a Chinese population. PMID: 17417066
    18. endometrial cell PGE2 biosynthesis was associated with PLA2G4C expression and activity PMID: 17459165
    19. The subcellular localization and enzymatic properties of cPLA2gamma with C-terminal FLAG-tag, was examined. PMID: 19501189

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor. Endoplasmic reticulum membrane; Lipid-anchor. Mitochondrion membrane; Lipid-anchor. Lipid droplet.
  • 组织特异性：
    Highly expressed in heart and skeletal muscle.
  • 数据库链接：

    HGNC: 9037

    OMIM: 603602

    KEGG: hsa:8605

    STRING: 9606.ENSP00000400036

    UniGene: Hs.631562