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PLA2G4D Antibody

  • 货号：
    CSB-PA008908
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q86XP0
  • 基因名：
  • 别名：
    cPLA2 delta antibody; cPLA2-delta antibody; cPLA2delta antibody; Cytosolic phospholipase A2 delta antibody; PA24D_HUMAN antibody; Phospholipase A2 group IVD antibody; phospholipase A2; group IVD (cytosolic) antibody; Pla2g4d antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human cPLA2-δ.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has a preference for linoleic acid at the sn-2 position.
  • 基因功能参考文献：
    1. These findings suggested that the polymorphism of PLA2G4D rs4924618 may have a protective influence on the SPTB susceptibility in a Chinese population, supporting a role for genetics in the association between PG synthesis and preterm birth. PMID: 28440406
    2. The findings suggest that PLA2 inhibition or CD1a blockade may have therapeutic potential for psoriasis. PMID: 27670592
    3. study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP, CBFA2T3, AMOTL1, FAT4, FBXO11, PLA2G4D, TRRAP and USH2A. PMID: 24349473
    4. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
    5. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
    6. cPLA(2)delta exhibits a unique distribution pattern compared with that of known cPLA(2) subtypes and may play a critical role in inflammation in psoriatic lesions PMID: 14709560
    7. Observational study of gene-disease association. (HuGE Navigator) PMID: 18686860
    8. Observational study of gene-disease association. (HuGE Navigator) PMID: 16213696

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  • 亚细胞定位：
    Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side.
  • 组织特异性：
    Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues. Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoid
  • 数据库链接：

    HGNC: 30038

    OMIM: 612864

    KEGG: hsa:283748

    STRING: 9606.ENSP00000290472

    UniGene: Hs.380225