PLCD1 Antibody

1. A loss of epidermal PLCdelta1 impairs epidermal barrier function through dysregulation of Ca2+ and p38 mitogen-activated protein kinase (MAPK) signaling. This study also reveals a possible link among PLCdelta1 downregulation, p38 MAPK hyperactivation, and barrier defects in psoriasis-like skin inflammation. PMID: 28430185
2. PLCD1 acts as a tumour suppressor, by KIF3A-mediated suppression of ERK1/2/beta-catenin/MMP7 signalling, at least in part, in breast cancer. PMID: 28423710
3. Nine of the 32 (28.1%) iCCA patients had gene mutations at chromosome 3p, totaling 11 mutations across five genes. Those included five (15.6%) BAP1 mutations, two each (6.3%) of CACNA2D3 and RASSF1 mutations, and one each (3.1%) of ATG7 and PLCD1 mutations. Six (18.8%) cases had concurrent loss of chromosome 3p and gene mutations. PMID: 29122566
4. The PLCdelta1 negatively regulates autophagy, and PLCdelta1 suppression contributes to the tolerance of CRC cells harboring KRAS mutations to nutrient deprivation and anti-cancer drug treatment. PMID: 28528980
5. Phospholipase C delta 1 is both a KLF15-regulated gene and a novel repressor of airway smooth muscle hypertrophy. PMID: 28375666
6. High PLC delta expression is associated with breast cancer. PMID: 28112359
7. slow phase of Gi/o-mediated TRPC4 activation was diminished by inhibiting RhoA or enhancing PLCdelta function PMID: 26755577
8. Both unsaturated and saturated dioleoyl-phosphatidylinositol-(4,5)-bisphosphate successfully recruited PHPLCdelta1 to cell membranes. PMID: 25995263
9. Neuropeptide Y decreased PLCD1 expression in HUVECs. PMID: 24903829
10. PLC-delta1 and TRPV6 are critical actor of Ca(2+) homeostasis in CF human bronchial epithelial cells. PMID: 25477137
11. Ectopic expression of PLCD1 inhibits breast tumor cell proliferation in vivo by inducing apoptosis and suppressed tumor cell migration by regulating cytoskeletal reorganization. PMID: 25655282
12. PLCdelta1 is required for maintenance of homeostasis in skin and metabolic tissues. [review] PMID: 23948486
13. Provide evidence for intramolecular interactions in the PLC-delta1 PH domain. PMID: 23388389
14. Genotyping using microsatellite markers linked the families to the gene PLCD1 on chromosome 3p22.2. Sequence analysis of the gene detected one novel (p.Ser740ArgfsX19) and one previously reported mutation (p.Arg437X). PMID: 23149345
15. A novel mutation in the PLCD1 gene, which leads to an aberrant splicing event, underlies autosomal recessive leuconychia. PMID: 22458588
16. PLCD1 acts as a functional tumor suppressor and may serve as a biomarker for possible early detection and prognosis of chronic myeloid leukemia. PMID: 22576628
17. Increased PLC-delta1 activity causes enhanced coronary vasomotility such as that seen in patients with coronary spastic angina. PMID: 22265909
18. Mutations in this gene cause hereditary porcelain nails. Review. PMID: 22078044
19. Significantly deregulated pathways in colorectal cancer were identified and repression of PLCD1 and PLCE1 expression, was validated. PMID: 21909432
20. these data show that mutations in PLCD1 underlie hereditary leukonychia, revealing a gene involved in molecular control of nail growth. PMID: 21665001
21. PLCD1 is silenced by promoter methylation in breast cancer. Silencing of PLCD1 is reversed by demethylation which leads to the disruption of cell cycle at G2/M phase in breast cancer, indicating that PLCD1 functions as a tumor suppressor in this tumor. PMID: 20657189
22. After PLC-delta 1 treatment with small interfering RNA, angiotensin II type 1 receptor-stimulated inositol phosphate formation is attenuated. PMID: 20018811
23. Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta PMID: 11960991
24. the PLC-delta1 promoter is under the control of NF-kappaB, which mediates the expression of PLC-delta due to Abeta42 PMID: 14550290
25. PLCdelta(1) and PLCdelta(4) are probably differentially regulated in distinct cellular compartments by PI(4,5)P(2) PMID: 15037625
26. Nuclear translocation of phospholipase C-delta1 is linked to the cell cycle and nuclear phosphatidylinositol 4,5-bisphosphate PMID: 15809301
27. the Ral-CaM complex defines a multifaceted regulatory mechanism for PLC-delta1 activation PMID: 15817490
28. In this review, recent findings regarding the molecular machineries and mechanisms of the nucleocytoplasmic shuttling of PLCdelta1 will be discussed. PMID: 16240320
29. These results support the model that activation of selected PLC isoforms at the cleavage furrow controls progression of cytokinesis through regulation of PIP2 levels PMID: 17041247
30. PLC delta 1 plays an important suppressive role in the development and progression of esophageal squamous cell carcinoma PMID: 18006814
31. Human ARHGAP6 protein possessing GTPase stimulating activity for RhoA on the catalytic properties of PLC-delta1, was studied. PMID: 18434237
32. Data are consistent with the idea that phospholipase C d1 and d3 isoforms support the growth and migration of normal and neoplastic mammary epithelial cells in vitro. PMID: 19344632
33. PLCD1 acts as a functional tumor suppressor involved in gastric carcinogenesis. PMID: 19448674

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HGNC: 9060

OMIM: 151600

KEGG: hsa:5333

STRING: 9606.ENSP00000430344

UniGene: Hs.80776