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PLCL1 Antibody

  • 货号：
    CSB-PA698627
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA698627(PLCL1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q15111
  • 基因名：
    PLCL1
  • 别名：
    Inactive phospholipase C-like protein 1 antibody; Inactive protein 1 antibody; Phospholipase C deleted in lung carcinoma antibody; Phospholipase C epsilon antibody; Phospholipase C like 1 antibody; Phospholipase C related but catalytically inactive protein antibody; Phospholipase C related, but catalytically inactive protein antibody; Phospholipase C-deleted in lung carcinoma antibody; Phospholipase C-related but catalytically inactive protein antibody; Phospholipase C-related catalytically antibody; PLC-L1 antibody; PLCE antibody; PLCL antibody; PLCL1 antibody; PLCL1_HUMAN antibody; PLDL1 antibody; PRIP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human PLCL1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.
  • 基因功能参考文献：
    1. susceptibility gene for dermatomyositis in Chinese patients with idiopathic inflammatory myopathies PMID: 26603167
    2. PRIP interacts with the catalytic subunits of PP1 and PP2A and the interactions are regulated by phosphorylation. [review] PMID: 23911386
    3. effect of DZP on PRIP-1 knockout mice was reduced PMID: 22128345
    4. In postmenopausal women, our results suggest that the PLCL1 rs7595412 polymorphism has no obvious effect on hip bone size and bone mineral density but may be associated with increased proportion of vertebral fracture and increased levels of osteocalcin PMID: 20030815
    5. PRIP-1 plays an important role in type A receptor signaling for gamma-aminobutyric acid in the brain PMID: 16952428
    6. PLCL1 is a novel gene associated with variation in hip bone size, which has a role in the pathogenesis of hip fractures PMID: 18776929

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  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain.
  • 数据库链接：

    HGNC: 9063

    OMIM: 600597

    KEGG: hsa:5334

    STRING: 9606.ENSP00000402861

    UniGene: Hs.153322