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PLIN4 Antibody

  • 货号：
    CSB-PA822286HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate
      All lanes: PLIN4 antibody at 2.7μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 135, 141 kDa
      Observed band size: 135 kDa
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA822286HA01HU at dilution of 1:100
    • Immunofluorescent analysis of PC-3 cells using CSB-PA822286HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品描述：

    CUSABIO produces the PLIN4 antibody by immunizing rabbits with the recombinant human PLIN4 protein (308-418AA). The resulting antibody is a polyclonal antibody and occurs as an unconjugated IgG. Its purity is greater than 95% using protein G purified. It only shows reactivity with human PLIN4 protein, also known as S3-12, which is highly expressed in white adipose tissue and coats lipid droplets in adipocytes to protect them from lipases. This PLIN4 antibody can be applied in ELISA, WB, IHC, and IF analyses.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PLIN4 Polyclonal antibody
  • Uniprot No.：
    Q96Q06
  • 基因名：
  • 别名：
    Adipocyte protein S3 12 antibody; Adipocyte protein S3-12 antibody; hCG1646516 antibody; KIAA1881 antibody; Perilipin-4 antibody; Plasma membrane associated protein S3 12 antibody; Plin 4 antibody; PLIN4 antibody; PLIN4_HUMAN antibody; S3 12 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Perilipin-4 protein (308-418AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PLIN4 Antibody (CSB-PA822286HA01HU)，的标记方式是Non-conjugated。对于PLIN4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA822286HB01HU PLIN4 Antibody, HRP conjugated ELISA
    FITC CSB-PA822286HC01HU PLIN4 Antibody, FITC conjugated
    Biotin CSB-PA822286HD01HU PLIN4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets.
  • 基因功能参考文献：
    1. Using synthetic lipids, we show that Plin4 amphipathic helix (AH) binds poorly to lipid bilayers but strongly interacts with pure triglycerides, acting as a coat and forming small oil droplets. Because Plin4 overexpression alleviates lipid droplet (LD) instability under conditions where their coverage by phospholipids is limiting, we propose that the Plin4 AH replaces the LD lipid monolayer, for example during LD growth. PMID: 29626194
    2. Studied weight loss in obese patients with Perilipin 4 (PLIN4), Fat mass and obesity-associated (FTO), and beta- adrenergic receptor 3 (ADRB3) polymorphisms treated with Garcinia cambogia/Glucomannan. Results suggest weight loss was attenuated in carriers of PLIN4, FTO, ADRB3 polymorphisms. PMID: 29361938
    3. PLIN2-PLIN5 proteins were all more abundant in women than in men (p = 0.037 and p < 0.0001, respectively), consistent with higher intramyocellular lipid content observed in female skeletal muscle. PMID: 22667335
    4. we found a significant association between one single-nucleotide polymorphism in PLIN4 and height but not with bone traits PMID: 22210160
    5. These results suggest variation at the PLIN4 locus, and its interaction with PUFA as a modulator of obesity related phenotypes, acts in part through creation of a miR-522 regulatory site PMID: 21533135
    6. Those findings indicate improvement and conservation of lifestyle depending on genetic predisposition in ADIPOQ, PLIN and LIPE should be encouraged. PMID: 20495294
    7. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20495294
    8. Characterization of homologous mouse gene product, plasma membrane associated protein, S3-12. PMID: 12840023

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  • 亚细胞定位：
    Cell membrane. Cytoplasm. Lipid droplet.
  • 蛋白家族：
    Perilipin family
  • 数据库链接：

    HGNC: 29393

    OMIM: 613247

    KEGG: hsa:729359

    STRING: 9606.ENSP00000301286

    UniGene: Hs.591387