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PLIN5 Antibody

  • 货号：
    CSB-PA804867LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: PLIN5 antibody at 2 μg/ml
      Lane 1: Mouse kidney tissue
      Lane 2: Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 51 kDa
      Observed band size: 51, 36 kDa
    • Immunofluorescent analysis of HepG2 cells using CSB-PA804867LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品描述：

    The PLIN5 polyclonal antibody is inducibly produced in the rabbit immunized with the recombinant human PLIN5 (305-453aa). It exists as the IgG isotype and liquid form. And it is purified by protein G affinity chromatography and reaches up to 95% in purity. This PLIN5 antibody can react with human- and mouse-origin PLIN5 proteins. It can recognize and detect the PLIN5 protein in three applications, including ELISA, WB, and IF.

    Its target protein PLIN5, also known as OXPAT, mainly regulates lipid metabolism, particularly fatty acid oxidation, in different tissues. Its role in energy metabolism and glucose homeostasis suggests that PLIN5 may have important implications for metabolic diseases, such as obesity, diabetes, and cardiovascular disease.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PLIN5 Polyclonal antibody
  • Uniprot No.：
    Q00G26
  • 基因名：
  • 别名：
    Lipid storage droplet protein 5 antibody; LSDA5 antibody; MLDP antibody; OXPAT antibody; Perilipin 5 antibody; Perilipin-5 antibody; PLIN5 antibody; PLIN5_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Perilipin-5 protein (305-453AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PLIN5 Antibody (CSB-PA804867LA01HU)，的标记方式是Non-conjugated。对于PLIN5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA804867LB01HU PLIN5 Antibody, HRP conjugated ELISA
    FITC CSB-PA804867LC01HU PLIN5 Antibody, FITC conjugated
    Biotin CSB-PA804867LD01HU PLIN5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE.
  • 基因功能参考文献：
    1. The data highlight a key role of PLIN5 in lipid droplets function, first by finely adjusting lipid droplets fatty acids supply to mitochondrial oxidation, and second acting as a protective factor against lipotoxicity in skeletal muscle. PMID: 27922115
    2. Notch1 expression is reduced and glucose-6-phosphatase and perilipin-5 (G6PC/PLIN5) are upregulated in liver biopsies from nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD) patients. PMID: 27428080
    3. High oxygen consumption in middle-aged men was reflected in higher perilipin 5 expression in skeletal muscle. PMID: 26447519
    4. PLIN5 was significantly colocated with ATGL, mitochondria and CGI-58, indicating a close association between the key lipolytic effectors in resting skeletal muscle. PMID: 25054327
    5. Perilipin 5 as a lipid droplet protein adapted to mitochondrial energy utilization PMID: 24535284
    6. Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5 PMID: 23129790
    7. PLIN5 likely plays an important role in intramyocellular lipid accumulation and oxidation, both of which increase with endurance training in human skeletal muscle. PMID: 22667335
    8. The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria. PMID: 22127648
    9. Perilipin 5 is the most recently established family member, highly expressed in oxidative tissues and could play an important role in regulating LD TAG hydrolysis in oxidative mammalian tissues. [Review] PMID: 21632259
    10. interaction of ATGL with CGI-58 increased lipolysis, whereas interaction of ATGL with perilipin 5 decreased lipolysis. PMID: 21393244
    11. Results indicate involvement of OXPAT and ADRP in muscular lipid accumulation and type 2 diabetes. PMID: 19602560

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  • 亚细胞定位：
    Lipid droplet. Cytoplasm. Mitochondrion.
  • 蛋白家族：
    Perilipin family
  • 组织特异性：
    Expressed in skeletal muscle, liver, heart and kidney.
  • 数据库链接：

    HGNC: 33196

    OMIM: 613248

    KEGG: hsa:440503

    STRING: 9606.ENSP00000371272

    UniGene: Hs.131034