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PMS1 Antibody

  • 货号：
    CSB-PA003824
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using PMS1 Polyclonal Antibody
    • Western Blot analysis of various cells using PMS1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P54277
  • 基因名：
    PMS1
  • 别名：
    DNA mismatch repair protein PMS1 antibody; FLJ98259 antibody; HNPCC3 antibody; hPMS1 antibody; Human homolog of yeast mutL antibody; Mismatch repair gene PMSL1 antibody; pms1 antibody; PMS1 postmeiotic segregation increased 1 (S. cerevisiae) antibody; PMS1 postmeiotic segregation increased 1 antibody; PMS1 protein homolog 1 antibody; PMS1_HUMAN antibody; PMSL1 antibody; Rhabdomyosarcoma antigen MU RMS 40.10B antibody; Rhabdomyosarcoma antigen MU RMS 40.10E antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PMS1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probably involved in the repair of mismatches in DNA.
  • 基因功能参考文献：
    1. Genome-wide association study identifies variants in PMS1 associated with serum ferritin in a Chinese population. PMID: 25162662
    2. These studies establish that the Mlh1-Pms1 endonuclease is required for MMR in a previously uncharacterized Exo1-independent MMR pathway. PMID: 24204293
    3. PMS1 is most likely deregulated by post-transcriptional modification in oral squamous cell carcinoma. PMID: 23608172
    4. hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA PMID: 11809883
    5. The expression of hMLH1 and hPMS1 was significantly low in some large B-cell lymphomas and in mantle cell lymphomas of the blastoid type and may be related to the natural history of these neoplasms. PMID: 11999575
    6. Data show that DNA damage induces the accumulation of hPMS1, hPMS2, and hMLH1 through ataxia-telangiectasia-mutated (ATM)-mediated protein stabilization. PMID: 15226443
    7. hPMS1 may be useful as CD4+ helper T cell antigens for immunotherapy of pancreatic cancer patients. PMID: 15856462
    8. In pstreplicative mismatch repair, this protein interacts wiwth MutL protein. PMID: 17148452

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    DNA mismatch repair MutL/HexB family
  • 数据库链接：

    HGNC: 9121

    OMIM: 600258

    KEGG: hsa:5378

    STRING: 9606.ENSP00000406490

    UniGene: Hs.111749