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PNCK Antibody

  • 货号：
    CSB-PA754178LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, Jurkat whole cell lysate, Raji whole cell lysate, U87 whole cell lysate, HepG2 whole cell lysate, Rat liver tissue, Mouse brain tissue, Mouse kidney tissue
      All lanes: PNCK antibody at 3.1µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 39, 41, 28, 47 kDa
      Observed band size: 39 kDa
    • IHC image of CSB-PA754178LA01HU diluted at 1:200 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品描述：

    The PNCK polyclonal antibody is a rabbit-derived antibody that has been specifically designed to target the PNCK protein. The immunogen used to generate this antibody is a recombinant human PNCK protein (1-115aa). The PNCK protein mainly acts as a serine/threonine kinase that plays a role in various cellular processes, including cell proliferation, migration, survival, and differentiation. PNCK overexpression has been detected in a variety of tumor types, including breast, ovarian, and prostate cancer, and can promote cancer cell proliferation, migration, and invasion.

    This PNCK antibody has been purified using protein G affinity chromatography and has a purity of >95%. It has been validated for use in various applications, including ELISA, WB, and IHC. And it shows broad reactivity with human, mouse, and rat samples.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PNCK Polyclonal antibody
  • Uniprot No.：
    Q6P2M8
  • 基因名：
    PNCK
  • 别名：
    Calcium/calmodulin dependent protein kinase type 1B antibody; Calcium/calmodulin-dependent protein kinase type 1B antibody; CaM KI beta antibody; CaM kinase I beta antibody; CaM kinase IB antibody; CaM-KI beta antibody; CaMK1b antibody; CaMKI beta antibody; CaMKI-beta antibody; EC 2.7.11.17 antibody; KCC1B_HUMAN antibody; MGC45419 antibody; PNCK antibody; Pregnancy up regulated non ubiquitously expressed CaM kinase antibody; Pregnancy up-regulated non-ubiquitously-expressed CaM kinase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Calcium/calmodulin-dependent protein kinase type 1B protein (1-115AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PNCK Antibody (CSB-PA754178LA01HU)，的标记方式是Non-conjugated。对于PNCK Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA754178LB01HU PNCK Antibody, HRP conjugated ELISA
    FITC CSB-PA754178LC01HU PNCK Antibody, FITC conjugated
    Biotin CSB-PA754178LD01HU PNCK Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1.
  • 基因功能参考文献：
    1. Pnck may be a marker of Trastuzumab resistance and possibly a therapeutic target in breast cancer. PMID: 25773930
    2. the relationship between PNCK and prognosis in clear cell renal cell carcinoma PMID: 23634203
    3. Pnck induces epidermal growth factor receptor degradation, most likely through perturbation of Hsp90 chaperone activity due to Hsp90 phosphorylation. Epidermal growth factor receptor degradation is coupled to proteasomal degradation of Pnck. PMID: 21325639
    4. Pnck induces ligand-independent EGFR degradation, and it may represent an attractive therapeutic target in EGFR-regulated oncogenesis. PMID: 18562482
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
  • 数据库链接：

    HGNC: 13415

    OMIM: 300680

    KEGG: hsa:139728

    STRING: 9606.ENSP00000405950

    UniGene: Hs.436667