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PNRC2 Antibody

  • 货号：
    CSB-PA018290LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: PNRC2 antibody at 4µg/ml + U251 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 16, 14 kDa
      Observed band size: 16 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018290LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PNRC2 Polyclonal antibody
  • Uniprot No.：
    Q9NPJ4
  • 基因名：
    PNRC2
  • 别名：
    0610011E17Rik antibody; D4Bwg0593e antibody; FLJ20312 antibody; MGC11707 antibody; MGC93828 antibody; MGC99541 antibody; OTTMUSP00000010360 antibody; OTTMUSP00000010366 antibody; pnrc2 antibody; PNRC2_HUMAN antibody; Proline rich nuclear receptor coactivator 2 antibody; Proline-rich nuclear receptor coactivator 2 antibody; RP11-4M23.5 antibody; RP23-161N17.3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Proline-rich nuclear receptor coactivator 2 protein (1-139AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PNRC2 Antibody (CSB-PA018290LA01HU)，的标记方式是Non-conjugated。对于PNRC2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA018290LB01HU PNRC2 Antibody, HRP conjugated ELISA
    FITC CSB-PA018290LC01HU PNRC2 Antibody, FITC conjugated
    Biotin CSB-PA018290LD01HU PNRC2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure.
  • 基因功能参考文献：
    1. UPF1 interacts with PNRC2 and that it triggers 5'-3' exonucleolytic decay of reporter transcripts in tethering assays. PNRC2 is probably an important mRNA decapping factor but that it does not appear to be required for nonsense-mediated mRNA decay. PMID: 29348139
    2. GR and PNRC2 interact in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation PMID: 25775514
    3. PNRC2 acts in synergy with Dcp1a to stimulate the decapping activity of Dcp2 by bridging the interaction between Dcp1a and Dcp2. PMID: 23085078
    4. Not only PNRC2 but also the corepressor TLE1 functioned as ERRgamma coactivator in a reporter gene analysis. PMID: 14651967
    5. PNRC2 plays an essential role in mammalian Nonsense-mediated mRNA decay (NMD), mediating the interaction between the NMD machinery and the decapping complex. PMID: 19150429

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  • 亚细胞定位：
    Nucleus. Cytoplasm, P-body.
  • 蛋白家族：
    PNRC family, PNRC2 subfamily
  • 组织特异性：
    Expressed in heart, lung, muscle and brain.
  • 数据库链接：

    HGNC: 23158

    OMIM: 611882

    KEGG: hsa:55629

    STRING: 9606.ENSP00000383587

    UniGene: Hs.512636