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POGZ Antibody

  • 货号：
    CSB-PA018299LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA018299LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018299LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) POGZ Polyclonal antibody
  • Uniprot No.：
    Q7Z3K3
  • 基因名：
    POGZ
  • 别名：
    KIAA0461 antibody; MGC71543 antibody; Pogo transposable element with ZNF domain antibody; POGZ antibody; POGZ_HUMAN antibody; putative protein product of Nbla00003 antibody; SUHW5 antibody; suppressor of hairy wing homolog antibody; Suppressor of hairy wing homolog 5 antibody; Zinc finger protein 280E antibody; Zinc finger protein 635 antibody; ZNF280E antibody; ZNF635 antibody; ZNF635M antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Pogo transposable element with ZNF domain protein (1-300AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，POGZ Antibody (CSB-PA018299LA01HU)，的标记方式是Non-conjugated。对于POGZ Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA018299LB01HU POGZ Antibody, HRP conjugated ELISA
    FITC CSB-PA018299LC01HU POGZ Antibody, FITC conjugated
    Biotin CSB-PA018299LD01HU POGZ Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.
  • 基因功能参考文献：
    1. In silico analysis and western blotting revealed this frameshift mutation generating truncated protein in peripheral blood lymphocytes, and this may disrupt several important domains of POGZ gene. Our finding broadens the spectrum of POGZ mutations and may help to understand the molecular basis of Intellectual disability (ID) and aid genetic counseling. PMID: 26763879
    2. Data suggest that loss of function variants in POGZ lead to an identifiable syndrome of neurodevelopmental disorders with specific phenotypic traits including intellectual disability. PMID: 26739615
    3. We find that POGZ is constitutively expressed across most tissues and has significantly higher levels of expression in the cerebellum and the pituitary gland. Disruption of POGZ is associated with intellectual disability and autism spectrum disorders PMID: 26942287
    4. The results reveal POGZ as an essential protein that links HP1alpha dissociation with Aurora B kinase activation during mitosis. PMID: 20562864
  • 相关疾病：
    White-Sutton syndrome (WHSUS)
  • 亚细胞定位：
    Nucleus. Chromosome. Cytoplasm.
  • 数据库链接：

    HGNC: 18801

    OMIM: 614787

    KEGG: hsa:23126

    STRING: 9606.ENSP00000271715

    UniGene: Hs.489873