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POLA2 Antibody

  • 货号：
    CSB-PA614517LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) POLA2 Polyclonal antibody
  • Uniprot No.：
    Q14181
  • 基因名：
  • 别名：
    AI573378 antibody; DNA directed DNA polymerase alpha 2 antibody; DNA polymerase alpha 70 kDa subunit antibody; DNA polymerase alpha subunit B antibody; DNA polymerase alpha subunit II antibody; DNA polymerase subunit alpha B antibody; DNA polymerase subunit II antibody; DPOA2_HUMAN antibody; FLJ21662 antibody; FLJ37250 antibody; polA2 antibody; Polymerase (DNA directed) alpha 2 (70kD subunit) antibody; Polymerase (DNA directed); alpha (70kD) antibody; Polymerase (DNA directed); alpha 2 accessory subunit antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human DNA polymerase alpha subunit B protein (101-400AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，POLA2 Antibody (CSB-PA614517LA01HU)，的标记方式是Non-conjugated。对于POLA2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA614517LB01HU POLA2 Antibody, HRP conjugated ELISA
    FITC CSB-PA614517LC01HU POLA2 Antibody, FITC conjugated
    Biotin CSB-PA614517LD01HU POLA2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively.
  • 基因功能参考文献：
    1. STN1-POLA2 interaction provides a basis for primase-polymerase alpha stimulation by human STN1. PMID: 28934486
    2. our findings showed that knockdown of POLA2 increases gemcitabine resistance in human lung cancer cells. We propose that POLA2 may play a role in gemcitabine sensitivity and can be used as a prognostic biomarker of patient outcome in NSCLC pathogenesis. PMID: 28155658
    3. POLA2+1747 GG/GA may be used as a prognostic biomarker of patient outcome in NSCLC pathogenesis PMID: 25521664
    4. Findings indicate that tethering of primase to the replisome by DNA polymerase alpha (pol alpha) is critical for the normal action of DNA replication forks in eukaryotic cells. PMID: 22593576
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    DNA polymerase alpha subunit B family
  • 数据库链接：

    HGNC: 30073

    KEGG: hsa:23649

    STRING: 9606.ENSP00000265465

    UniGene: Hs.201897