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POLG2 Antibody

  • 货号：
    CSB-PA883399LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) POLG2 Polyclonal antibody
  • Uniprot No.：
    Q9UHN1
  • 基因名：
    POLG2
  • 别名：
    DNA directed DNA polymerase gamma 2 antibody; DNA polymerase gamma accessory 55 kDa subunit antibody; DNA polymerase subunit gamma 2; mitochondrial antibody; DNA polymerase subunit gamma-2 antibody; DPOG2_HUMAN antibody; HP55 antibody; mitochondrial antibody; Mitochondrial DNA polymerase accessory subunit antibody; Mitochondrial DNA polymerase subunit gamma 2 antibody; Mitochondrial polymerase gamma 2 antibody; MtPolB antibody; OTTMUSP00000003758 antibody; p55 antibody; PEOA4 antibody; POLB antibody; PolG beta antibody; PolG-beta antibody; POLG2 antibody; POLGB antibody; Polymerase (DNA directed); gamma 2; accessory subunit antibody; Polymerase; gamma 2 antibody; RP23-247J12.3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human DNA polymerase subunit gamma-2, mitochondrial protein (1-485AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，POLG2 Antibody (CSB-PA883399LA01HU)，的标记方式是Non-conjugated。对于POLG2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA883399LB01HU POLG2 Antibody, HRP conjugated ELISA
    FITC CSB-PA883399LC01HU POLG2 Antibody, FITC conjugated
    Biotin CSB-PA883399LD01HU POLG2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mitochondrial polymerase processivity subunit. It regulates the polymerase and exonuclease activities promoting processive DNA synthesis. Binds to ss-DNA.
  • 基因功能参考文献：
    1. This is the first report of a patient with a homozygous mutation in POLG2 and with a clinical presentation of severe hepatic failure and mitochondrial depletion. PMID: 27592148
    2. Results show that polymorphisms at POLG2 and POLRMT increased risk of oral cancer and leukoplakia, respectively, probably modulating synthesis and activity of the enzymes. PMID: 26403317
    3. Mitochondrial DNA (mtDNA) content plays an important role in energy production and sustaining normal physiological function. PMID: 24524965
    4. The s describe the molecular characterization of a potential dominant POLG2 mutation (p.R369G) in a patient with autosomal dominant progressive external ophthalmoplegia and multiple mtDNA deletions. PMID: 22155748
    5. Data show that rs17650301 in POLG2 is a good candidate marker for UBC invasiveness in Japanese males. PMID: 21734712
    6. The biochemical analysis helps explain the pathogenesis of POLG2 mutations in mitochondrial disease. PMID: 21555342
    7. human pol gammaB exhibits a catalytic subunit- and substrate DNA-dependent dimerization. PMID: 19858216
    8. PolB gamma can bind double-stranded DNA and may play a role in DNA replication or repair PMID: 12379656
    9. Study represents the first structure-function analysis of the thumb subdomain in pol gamma and examines the consequences of mitochondrial disease mutations in this region. PMID: 19478085
    10. Both increased and decreased expression of POLGbeta altered nucleoid structure and precipitated a marked decrease in 7S DNA molecules, which form short displacement-loops on mitochondrial DNA. PMID: 19625489

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  • 相关疾病：
    Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 4 (PEOA4)
  • 亚细胞定位：
    Mitochondrion.
  • 数据库链接：

    HGNC: 9180

    OMIM: 604983

    KEGG: hsa:11232

    STRING: 9606.ENSP00000442563

    UniGene: Hs.437009