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POLR2C Antibody

  • 货号：
    CSB-PA018329LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: PC-3 whole cell lysate, Mouse kidney tissue
      All lanes: POLR2C antibody at 3.5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 32 kDa
      Observed band size: 32 kDa
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA018329LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA018329LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) POLR2C Polyclonal antibody
  • Uniprot No.：
    P19387
  • 基因名：
    POLR2C
  • 别名：
    DNA directed RNA polymerase II 33 kDa polypeptide antibody; DNA directed RNA polymerase II subunit C antibody; DNA directed RNA polymerase II subunit RPB3 antibody; DNA-directed RNA polymerase II 33 kDa polypeptide antibody; DNA-directed RNA polymerase II subunit C antibody; DNA-directed RNA polymerase II subunit RPB3 antibody; hRPB33 antibody; hsRPB3 antibody; POLR 2C antibody; POLR2 C antibody; Polr2c antibody; Polymerase (RNA) II (DNA directed) polypeptide C; 33kDa antibody; polymerase RNA II DNA directed polypeptide C 33kDa antibody; RNA polymerase II polypeptide C antibody; RNA polymerase II subunit 3 antibody; RNA polymerase II subunit B3 antibody; RPB 3 antibody; RPB3 antibody; RPB3_HUMAN antibody; RPB31 antibody; RPB33 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human DNA-directed RNA polymerase II subunit RPB3 protein (2-275AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，POLR2C Antibody (CSB-PA018329LA01HU)，的标记方式是Non-conjugated。对于POLR2C Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA018329LB01HU POLR2C Antibody, HRP conjugated ELISA
    FITC CSB-PA018329LC01HU POLR2C Antibody, FITC conjugated
    Biotin CSB-PA018329LD01HU POLR2C Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft.
  • 基因功能参考文献：
    1. FUS low-complexicity phase separates to recruit RNA polymerase II C-terminal domain in vitro. PMID: 26455390
    2. These findings suggest that N-terminus of Rpb3 selectively inhibits Rpb3-high-expression hepatocellular carcinoma cells proliferation. N-terminus of Rpb3 may be useful in treating patients diagnosed with Rpb3-high-expression hepatocellular carcinoma. PMID: 25211001
    3. eEF1gamma, in addition to its role in translation elongation complex, is involved in regulating Vimentin gene by contacting both pol II and the Vimentin promoter region and shuttling/nursing the Vimentin mRNA PMID: 21217813
    4. interaction between RPB3 and ATF4 PMID: 12860379
    5. Rpb3 is a potential nuclear target of insulin-like growth factor binding protein-3 PMID: 16455777

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family
  • 数据库链接：

    HGNC: 9189

    OMIM: 180663

    KEGG: hsa:5432

    STRING: 9606.ENSP00000219252

    UniGene: Hs.79402