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POLR2E Antibody

  • 货号：
    CSB-PA018332LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) POLR2E Polyclonal antibody
  • Uniprot No.：
    P19388
  • 基因名：
    POLR2E
  • 别名：
    and III subunit ABC1 antibody; and III subunit RPABC1 antibody; DNA directed RNA polymerase II 23 kda polypeptide antibody; DNA directed RNA polymerase II 23 kDa polypeptide antibody; DNA directed RNA polymerase II polypeptide E antibody; DNA directed RNA polymerase II subunit E antibody; DNA directed RNA polymerases I II and III subunit RPABC1 antibody; DNA-directed RNA polymerase II 23 kDa polypeptide antibody; DNA-directed RNA polymerase II subunit E antibody; DNA-directed RNA polymerases I antibody; hRPB25 antibody; hsRPB5 antibody; II antibody; Polr2e antibody; Polymerase (RNA) II (DNA directed) polypeptide E (25kD) antibody; Polymerase (RNA) II (DNA directed) polypeptide E, 25kDa antibody; RNA polymerases I antibody; RNA polymerases I, II, and III subunit ABC1 antibody; RPAB1_HUMAN antibody; RPABC1 antibody; RPB5 antibody; RPB5 homolog antibody; XAP4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human DNA-directed RNA polymerases I, II, and III subunit RPABC1 protein (1-210AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，POLR2E Antibody (CSB-PA018332LA01HU)，的标记方式是Non-conjugated。对于POLR2E Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA018332LB01HU POLR2E Antibody, HRP conjugated ELISA
    FITC CSB-PA018332LC01HU POLR2E Antibody, FITC conjugated
    Biotin CSB-PA018332LD01HU POLR2E Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.
  • 基因功能参考文献：
    1. POLR2E rs3787016T allele was associated with an increased cancer risk in Chinese population PMID: 29724531
    2. POLR2E rs3787016 C/T and HULC rs7763881 were associated with a significantly decreased risk for ESCC 0.005). ANRIL rs2151280 T/C SNP was not associated with risk of ESCC. PMID: 25874495
    3. ELL has an early and essential role during rapid high-amplitude gene expression that is required for both Pol II pause site entry and release PMID: 22252557
    4. crystal of RPB5 diffracted to 2.8 A resolution and belonged to space group P4(3)2(1)2. PMID: 22102239
    5. RPB5-mediating protein is required for the proliferation of hepatocellular carcinoma cells. PMID: 21310960
    6. Results pinpoint critical residues for RNA polymerase II subunit 5 binding to RAP30 and/or to HBx, and identify these residues in both mammalian cells and in an in vitro binding assay. PMID: 16169872

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family
  • 数据库链接：

    HGNC: 9192

    OMIM: 180664

    KEGG: hsa:5434

    STRING: 9606.ENSP00000215587

    UniGene: Hs.24301