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POLR2F Antibody

  • 货号：
    CSB-PA018333GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P61218
  • 基因名：
    POLR2F
  • 别名：
    POLR2F antibody; POLRF antibody; DNA-directed RNA polymerases I antibody; II antibody; and III subunit RPABC2 antibody; RNA polymerases I antibody; II antibody; and III subunit ABC2 antibody; DNA-directed RNA polymerase II subunit F antibody; DNA-directed RNA polymerases I antibody; II antibody; and III 14.4 kDa polypeptide antibody; RPABC14.4 antibody; RPB14.4 antibody; RPB6 homolog antibody; RPC15 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human POLR2F
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds.
  • 基因功能参考文献：
    1. These results suggest that RPAP2 controls Pol II activity through a direct interaction with Rpb6 PMID: 25639305
    2. Solution structure of the hRPABC14.4 subunit of human RNA polymerases.(RPABC14.4 ?) PMID: 10542096
    3. POLR2F and PRNP exhibited elevated levels in carcinomas compared to normal tissue samples suggesting a possible role for these molecules in colorectal cancer. PMID: 18505059
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family
  • 数据库链接：

    HGNC: 9193

    OMIM: 604414

    KEGG: hsa:5435

    STRING: 9606.ENSP00000403852

    UniGene: Hs.436578