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POLR3G Antibody

  • 货号：
    CSB-PA005904
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of PC12 cells using POLR3G Polyclonal Antibody.
  • 其他：

产品详情

  • Uniprot No.：
    O15318
  • 基因名：
    POLR3G
  • 别名：
    DNA directed RNA polymerase III 32 kDa polypeptide antibody; DNA-directed RNA polymerase III subunit G antibody; DNA-directed RNA polymerase III subunit RPC7 antibody; Polr3g antibody; Polymerase (RNA) III (DNA directed) polypeptide G (32kD) antibody; RNA polymerase III 32 kDa subunit antibody; RNA polymerase III subunit C7 antibody; RPC32 antibody; RPC7 antibody; RPC7_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human POLR3G.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF- Kappa-B through the RIG-I pathway.
  • 基因功能参考文献：
    1. POLR3G regulates small non-coding RNAs and RNA splicing in human pluripotent stem cells. The primary function of POLR3G is in the maintenance rather than repression of transcription. PMID: 28494942
    2. Decreased levels of POLR3G result in loss of pluripotency and promote differentiation of human embryonic stem cells to all three germ layers but have no effect on cell apoptosis. PMID: 21898682
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Eukaryotic RPC7 RNA polymerase subunit family
  • 组织特异性：
    Barely detectable in differentiated tissues. Expressed in embryonic stem cells and in other dividing cells, such as some tumor cell lines.
  • 数据库链接：

    HGNC: 30075

    OMIM: 617456

    KEGG: hsa:10622

    STRING: 9606.ENSP00000382058

    UniGene: Hs.282387