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PPM1G Antibody

  • 货号：
    CSB-PA018494GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O15355
  • 基因名：
    PPM1G
  • 别名：
    MGC1675 antibody; MGC2870 antibody; OTTHUMP00000123426 antibody; PP2C antibody; PP2C gamma antibody; PP2C-gamma antibody; PP2CG antibody; PP2Cgamma antibody; PPM1G antibody; PPM1G_HUMAN antibody; PPP2CG antibody; Protein phosphatase 1C antibody; Protein phosphatase 1G antibody; Protein phosphatase 2 catalytic subunit gamma isoform antibody; Protein phosphatase 2C gamma isoform antibody; Protein phosphatase 2C isoform gamma antibody; Protein phosphatase magnesium dependent 1 gamma antibody; Protein phosphatase magnesium-dependent 1 gamma antibody; Protein phosphatase Mg2+/Mn2+ dependent 1G antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PPM1G
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. PPM1G phosphatase directly binds 7SK RNA and the kinase inhibitor Hexim1 once P-TEFb has been released from the 7SK snRNP. PMID: 26324325
    2. Hypermethylation in the 3'-protein-phosphatase-1G (PPM1G) gene locus was associated with alcohol use disorder. PMID: 25982659
    3. PPM1G inactivates monomeric WWP2 and promotes the assembly of WWP2-WWP1 heterodimeric complex. PMID: 25071155
    4. PPM1G dephosphorylates the P-TEFb kinase T loop to disassemble the 7SK snRNP. PMID: 24316072
    5. study has identified protein phosphatase PPM1G as a novel regulator of cap-dependent protein translation by negatively controlling the phosphorylation of 4E-BP1. PMID: 23814053
    6. ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage PMID: 22361354
    7. The degradation of p21(WAF1/CIP1) induced by PP2Cgamma was mediated in a proteasome-dependent manner. PMID: 17054950
    8. Protein phosphatase 2C gamma mediates histone dephosphorylation/exchange in response to DNA damage or checkpoint recovery in higher eukaryotes. PMID: 17074886
    9. PP2Cgamma modulates alternative splicing of specific pre-mRNAs coregulated by YB-1. PMID: 17572683
    10. an interplay between PPM1G and unrip determine compartment-specific phosphorylation patterns, localization, and function of the SMN complex PMID: 17984321
    11. PP2Cgamma is a novel regulator of p21(Cip1/WAF1) protein stability via the Akt signaling pathway. PMID: 19538940
    12. Functional study of the mouse homolog PMID: 9271424

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  • 亚细胞定位：
    Cytoplasm. Membrane; Lipid-anchor.
  • 蛋白家族：
    PP2C family
  • 组织特异性：
    Widely expressed. Most abundant in testis, skeletal muscle, and heart.
  • 数据库链接：

    HGNC: 9278

    OMIM: 605119

    KEGG: hsa:5496

    STRING: 9606.ENSP00000264714

    UniGene: Hs.643951