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PPM1K Antibody

  • 货号：
    CSB-PA822697LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, Mouse skeletal muscle tissue
      All lanes: PPM1K antibody at 2.7µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 41, 26, 17 kDa
      Observed band size: 41 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA822697LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PPM1K Polyclonal antibody
  • Uniprot No.：
    Q8N3J5
  • 基因名：
    PPM1K
  • 别名：
    BDP antibody; mitochondrial antibody; MSUDMV antibody; PP2C domain containing protein phosphatase 1K antibody; PP2C domain-containing protein phosphatase 1K antibody; PP2C kappa antibody; PP2C like mitochondrial protein antibody; PP2C type mitochondrial phosphoprotein phosphatase antibody; PP2C-kappa antibody; PP2C-like mitochondrial protein antibody; PP2C-type mitochondrial phosphoprotein phosphatase antibody; PP2Ckappa antibody; PP2CM antibody; PPM1K antibody; PPM1K_HUMAN antibody; Protein phosphatase 1K antibody; Protein phosphatase 1K; mitochondrial antibody; Protein phosphatase 2C isoform kappa antibody; Protein phosphatase Mg2+/Mn2+ dependent 1K antibody; PTMP antibody; UG0882E07 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Protein phosphatase 1K, mitochondrial protein (30-372AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PPM1K Antibody (CSB-PA822697LA01HU)，的标记方式是Non-conjugated。对于PPM1K Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA822697LB01HU PPM1K Antibody, HRP conjugated ELISA
    FITC CSB-PA822697LC01HU PPM1K Antibody, FITC conjugated
    Biotin CSB-PA822697LD01HU PPM1K Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.
  • 基因功能参考文献：
    1. Branched chain amino acids related genetic variant rs1440581 was associated with an increased risk of incident T2 Diabetes in a Chinese population. This variant might modify effect of weight gain on development in Insulin resistance. PMID: 29855804
    2. PPM1K rs1440581 may affect changes in glucose metabolism during weight loss, and this effect is dependent on dietary fat and carbohydrate intakes. PMID: 28768654
    3. miR-204 and miR-211 directly repress PPM1K expression via 3'UTR. PMID: 26592513
    4. Overweight people with the C allele of the branched-chain amino acid/aromatic amino acid ratio-associated variant rs1440581 may benefit less in weight loss and improved insulin sensitivity than those without it on a energy-restricted high-fat diet. PMID: 23446828
    5. The 2.4 A PP2Cm structure reveals a central beta-sandwich with two bound metal ions in the active-site cleft. PMID: 22291014
    6. A novel member of human protein phosphatase 2C gene family named PP2Ckappa was isolated from a human fetal brain cDNA library. PMID: 16685424
    7. The cloned phosphatase has a mitochondrial leader sequence and its amino acid sequence places it in the PP2C family like two known mitochondrial phosphatases. PMID: 17336929

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  • 相关疾病：
    Maple syrup urine disease, mild variant (MSUDMV)
  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    PP2C family
  • 数据库链接：

    HGNC: 25415

    OMIM: 611065

    KEGG: hsa:152926

    STRING: 9606.ENSP00000295908

    UniGene: Hs.43744