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PPP1R1C Antibody

  • 货号：
    CSB-PA007453
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q8WVI7
  • 基因名：
    PPP1R1C
  • 别名：
    PPP1R1C antibody; Protein phosphatase 1 regulatory subunit 1C antibody; Inhibitor-5 of protein phosphatase 1 antibody; IPP5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human PPP1R1C.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May increase cell susceptibility to TNF-induced apoptosis.
  • 基因功能参考文献：
    1. The data demonstrate a novel role for 8-60hIPP5(m) in the control of G2/M cell cycle progression, a process that involves the activation of ATM/p53/p21cip1/waf1/Cdc2/ cyclin B1 pathways. PMID: 24935604
    2. IPP5 mutations are associated with response to paclitaxel in cervical cancer. PMID: 25339026
    3. The effect of IPP5 on tumor growth and the underlying molecular mechanisms were investigated by overexpression of IPP5 in HeLa cells, a human cervical carcinoma cell line. PMID: 22939397
    4. Overexpression of active mutant IPP5 inhibited anchorage-dependent growth and induced apoptosis in HeLa cells, which may be attributed to the up-regulation of p21, p53 and Bcl-2-antagonist/killer, and down-regulation of Bcl-2 and Bcl-X(L). PMID: 19874272
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein phosphatase inhibitor 1 family
  • 数据库链接：

    HGNC: 14940

    OMIM: 613240

    KEGG: hsa:151242

    STRING: 9606.ENSP00000386359

    UniGene: Hs.10941