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  4. PPP1R2 (Ab-120/121) Antibody

PPP1R2 (Ab-120/121) Antibody

  • 货号：
    CSB-PA438934
  • 规格：
    ￥2024
  • 图片：
    • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using PPP1R2 (Ab-120/121) antibody.
    • Western blot analysis of extracts from Jurkat cells, using PPP1R2 (Ab-120/121) antibody.
    • Western blot analysis of extracts from JK cells (Lane 2), using PPP1R2 (Ab-120/121) antiobdy. The lane on the left is treated with synthesized peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PPP1R2 Polyclonal antibody
  • Uniprot No.：
    P41236
  • 基因名：
    PPP1R2
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized non-phosphopeptide derived from Human PPP1R2 around the phosphorylation site of serine 120 and serine 121 (Q-E-S(p)-S(p)-G-E).
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibitor of protein-phosphatase 1.
  • 基因功能参考文献：
    1. The results show that contrary to initial observations PPP1R2-related pseudogenes are not simple bystanders of the evolutionary process but may rather be at the origin of genes with novel functions. PMID: 24195737
    2. The potential phosphosites in PPP1R2 are substituted by non-phosphorylable residues, T73P and S87R, in PPP1R2P3. PMID: 23506001
    3. Pin1 and phosphatase inhibitor-2 are conserved among eukaryotes from yeast to humans and make an ancient partnership that provides a means for regulating Pin1 specificity and function. PMID: 21714498
    4. Inh2 can enhance the kinase activity of the Nek2.PP1C complex via inhibition of phosphatase activity to initiate centrosome separation PMID: 12221103
    5. first demonstration that glycogen synthase kinase-3beta associates with PP1C/I-2 complex and phosphorylates I-2 at T72 in intact cells PMID: 12761178
    6. These results indicate that the protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation induced by KCl and that GSK3 activity regulates SERCA2 levels. PMID: 16987514
    7. Results suggest that phosphatase inhibitor 2 localizes to the primary cilium of human retinal epithelial cells where it affects both Ser/Thr phosphorylation and is required for full tubulin acetylation. PMID: 19036150
    8. Studies in hamster indicate that modulation of type 1 protein phosphatase (PP1) activity by inhibitor-2 (INH-2) provides a potential new treatment for heart failure without activating protein kinase A (PKA) signaling. PMID: 16627625

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  • 蛋白家族：
    Protein phosphatase inhibitor 2 family
  • 数据库链接：

    HGNC: 9288

    OMIM: 601792

    KEGG: hsa:5504

    STRING: 9606.ENSP00000328178

    UniGene: Hs.535731