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PPP1R3A Antibody

  • 货号：
    CSB-PA030172
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q16821
  • 基因名：
  • 别名：
    Glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle antibody; Glycogen associated regulatory subunit of protein phosphatase 1 antibody; GM antibody; PP1G antibody; PPP1R3 antibody; PPP1R3A antibody; PPR3A_HUMAN antibody; Protein phosphatase 1 glycogen-associated regulatory subunit antibody; Protein phosphatase 1 glycogen-targeting subunit, muscle antibody; Protein phosphatase 1 regulatory subunit 3A antibody; Protein phosphatase 1 regulatory subunit GM antibody; protein phosphatase 1, regulatory (inhibitor) subunit 3A antibody; Protein phosphatase 1, regulatory subunit 3 antibody; Protein phosphatase type-1 glycogen targeting subunit antibody; RG1 antibody; Serine /threonine specific protein phosphatase antibody; Type 1 protein phosphatase skeletal muscle glycogen targeting subunit antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PPP1R3A.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase.
  • 基因功能参考文献：
    1. Variant in PPP1R3A is associated with type 2 diabetes. PMID: 29948331
    2. In the univariate analyses, TP53, PPP1R3A, and KMT2B were significantly more frequently mutated in interval cancers than in screen-detected cancers. PMID: 27587435
    3. results demonstrate that hScrib acts as a scaffold to integrate the control of the PP1gamma and ERK signaling pathways and explains how disruption of hScrib localisation can contribute towards the development of human malignancy PMID: 23359326
    4. A joint effect between the Asp905 and BMI increases the risk of type 2 diabetes, and Asp905Tyr and ARE polymorphism of PPP1R3 gene are not the major diabetogenic gene variants in Chinese population. PMID: 11793847
    5. G(M) promotes glycogen storage and inversely regulates glycogen synthase and glycogen phosphorylase activities, while, specifically, synthase phosphatase activity of G(M)-PP1 is inhibited by glycogen. PMID: 12941760
    6. Among the largest cohort of nondiabetic subjects (Caucasian, n = 112), the presence of the deletion allele (ARE-2) was associated with insulin resistance and hyperandrogenemia. PMID: 15181086
    7. Inactivation of PPP1R3 gene is associated with tumor progression and metastasis of colorectal cancers PMID: 15870946
    8. PPP1R3A C1984DeltaAG (stop codon 668) isthe 1st prevalent mutation that directly impairs glycogen synthesis & decreases glycogen levels in human skeletal muscle. It is present in approximately 1 in 70 UK whites. PMID: 18232732

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  • 相关疾病：
    Diabetes mellitus, non-insulin-dependent (NIDDM)
  • 亚细胞定位：
    Membrane; Single-pass membrane protein.
  • 组织特异性：
    Skeletal muscle and heart.
  • 数据库链接：

    HGNC: 9291

    OMIM: 125853

    KEGG: hsa:5506

    STRING: 9606.ENSP00000284601

    UniGene: Hs.458309