Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. PPP1R3C Antibody

PPP1R3C Antibody

  • 货号：
    CSB-PA030174
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9UQK1
  • 基因名：
  • 别名：
    OTTHUMP00000020089 antibody; Phosphatase 1, regulatory inhibitor subunit 5 antibody; PP1 subunit R5 antibody; ppp1r3c antibody; PPP1R5 antibody; PPR3C_HUMAN antibody; Protein phosphatase 1 inhibitor 3C antibody; Protein phosphatase 1 regulatory subunit 3C antibody; Protein phosphatase 1 regulatory subunit 5 antibody; protein phosphatase 1, regulatory (inhibitor) subunit 3C antibody; Protein targeting to glycogen antibody; PTG antibody; R5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Monkey
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PTG.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.
  • 基因功能参考文献：
    1. PPP1R3C, a novel hypermethylated gene in colorectal cancer, may play a critical role in cancer cell growth in association with glucose levels. PMID: 25846879
    2. detection of methylation of PPP1R3C alone or in combination with EFHD1 in plasma DNA showed high sensitivity and specificity in CRC detection, and may be useful detection method for CRC, especially for early-stage CRCs. PMID: 24861485
    3. Findings suggest that variations in PTG may condition the course of Lafora disease and establish PTG as a potential target for pharmacogenetic and therapeutic approaches. PMID: 21738631
    4. Results demonstrated that HIF1 promotes glycogen accumulation through regulating PPP1R3C expression under hypoxia, which revealed a novel metabolic adaptation of cells to hypoxia. PMID: 20888814
    5. phosphorylation of R5/PTG at Ser-8 by AMPK accelerates its laforin/malin-dependent ubiquitination and subsequent proteasomal degradation, which results in a decrease of its glycogenic activity. PMID: 19171932

    显示更多

    收起更多

  • 数据库链接：

    HGNC: 9293

    OMIM: 602999

    KEGG: hsa:5507

    STRING: 9606.ENSP00000238994

    UniGene: Hs.303090