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PPP1R7 Antibody

  • 货号：
    CSB-PA030176
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q15435
  • 基因名：
    PPP1R7
  • 别名：
    PPP1R7 antibody; SDS22 antibody; Protein phosphatase 1 regulatory subunit 7 antibody; Protein phosphatase 1 regulatory subunit 22 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Sds22.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of protein phosphatase 1.
  • 基因功能参考文献：
    1. a Fra-1-miR-134 axis drives a positive feedback loop that amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells. PMID: 27685628
    2. Mechanistically, the phosphorylation of Sds22 by PLK1 strengthens the binding of Sds22 to PP1 and inhibits the dephosphorylation of Thr(232) of Aurora B to ensure a robust, error-free metaphase-anaphase transition. PMID: 27557660
    3. there is a second, parallel signalling pathway which triggers the relaxation of the polar cell cortex at mid anaphase--independent of furrow formation, centrosomes and microtubules, pathway depends on PP1 phosphatase and regulatory subunit Sds22 PMID: 26168397
    4. a model in which I3 regulates an SDS22-mediated PP1 activation step in solution that precedes SDS22 dissociation and transfer of PP1 to kinetochores, and which is required for PP1 to efficiently antagonize Aurora B. PMID: 25298395
    5. It was shown that Repo-Man and Sds22 contribute to timely Aurora B kinase substrate dephosphorylation on anaphase chromatin. PMID: 22801782
    6. human Sds22 is focally deleted and downregulated in multiple carcinomas, and this downregulation correlates with tumor progression, suggesting that sds22 inactivation may contribute to tumorigenesis and metastatic potential PMID: 21399659
    7. Sds22 specifically defines protein phosphatase 1 function and localization in mitosis. PMID: 20921135

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    SDS22 family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 9295

    OMIM: 602877

    KEGG: hsa:5510

    STRING: 9606.ENSP00000234038

    UniGene: Hs.36587