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PPP2R2A Antibody

  • 货号：
    CSB-PA018564LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat brain tissue, Mouse brain tissue, Mouse liver tissue, Mouse kidney tissue
      All lanes: PPP2R2A antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 52, 53 kDa
      Observed band size: 52 kDa
    • Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA018564LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA018564LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PPP2R2A Polyclonal antibody
  • Uniprot No.：
    P63151
  • 基因名：
  • 别名：
    2ABA_HUMAN antibody; Alpha isoform of regulatory subunit B55 protein phosphatase 2 antibody; B55A antibody; B55ALPHA antibody; calcineurin antibody; PP2A subunit B B alpha isoform antibody; PP2A subunit B B55 alpha isoform antibody; PP2A subunit B isoform alpha antibody; PP2A subunit B isoform B55-alpha antibody; PP2A subunit B isoform PR55-alpha antibody; PP2A subunit B isoform R2-alpha antibody; PP2A subunit B PR55 alpha isoform antibody; PP2A subunit B R2 alpha isoform antibody; PPP2R2A antibody; PR52A antibody; PR55A antibody; Protein phosphatase 2 (formerly 2A) regulatory subunit B (PR 52) alpha isoform antibody; Protein phosphatase 2 (formerly 2A); regulatory subunit B (PR52); alpha isoform antibody; Protein phosphatase 2 regulatory subunit B alpha antibody; Protein phosphatase 2 regulatory subunit B alpha isoform antibody; Protein phosphatase 2 regulatory subunit Balpha antibody; Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform antibody; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform antibody; Testicular tissue protein Li 156 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform protein (2-149AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PPP2R2A Antibody (CSB-PA018564LA01HU)，的标记方式是Non-conjugated。对于PPP2R2A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA018564LB01HU PPP2R2A Antibody, HRP conjugated ELISA
    FITC CSB-PA018564LC01HU PPP2R2A Antibody, FITC conjugated
    Biotin CSB-PA018564LD01HU PPP2R2A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint.
  • 基因功能参考文献：
    1. Data show that SAM Domain and HD Domain-Containing Protein 1 (SAMHD1) is specifically targeted by protein phosphatase 2 regulatory subunit Balpha protein (PP2A-B55alpha) holoenzymes during mitotic exit. PMID: 29884836
    2. the data suggested that miR614 promoted cell proliferation and inhibited cell apoptosis of ovarian cancer (OC) cells by targeting PPP2R2A, and may therefore act as a potential target for OC therapy in the future. PMID: 29532877
    3. these results provide a novel insight into the role of PP2A-B55alpha as a novel meiotic and embryonic competence factor at the onset of life. PMID: 28439046
    4. we propose that the Smad4-Pitx2-PPP2R2A axis, a new signaling pathway, suppresses the pancreatic carcinogenesis PMID: 26848620
    5. These data unravel B55alpha as a PHD2 substrate and highlight a role for PHD2-B55alpha in the response to nutrient deprivation. PMID: 28329677
    6. results suggest that PR55alpha promotes pancreatic cancer development by sustaining hyperactivity of multiple oncogenic signaling pathways, including AKT, ERK, and Wnt PMID: 26893480
    7. miR-222 targets protein phosphatase 2A subunit B in bladder cancer cells. PMID: 26800397
    8. miR-556-5p functions as an onco-miRNA and participates in prostate cancer carcinogenesis by suppressing PPP2R2A expression. PMID: 26297546
    9. Data show that breast cancer (BC) with PPP2R2A deletions are associated with worse overall survival, and the combination of altered PPP2R2A and high CCND1 expression define a subgroup of luminal-like BC patients with a high risk of relapse and death. PMID: 25879784
    10. overexpression of miR-892a may provide a selective growth promotion for colorectal cancer cells by direct suppression of PPP2R2A expression. PMID: 26054685
    11. miR-136 may play an important role during TGF-beta1-induced proliferation arrest by targeting PPP2R2A in keratinocytes. PMID: 25654102
    12. Data suggest livers of biliary atresia subjects exhibit overexpression of MIR222 (microRNA 222); this appears to contribute to liver fibrosis (and in vitro cell proliferation) by targeting PPP2R2A (protein phosphatase 2A subunit B) and Akt signaling. PMID: 25238119
    13. The suppression of B55alpha activates signaling pathways that could support leukemia cell survival. PMID: 24858343
    14. Identification of the adenovirus E4orf4 protein binding site on the B55alpha and Cdc55 regulatory subunits of PP2A: Implications for PP2A PMID: 24244166
    15. miR-136 promotes Erk1/2 phosphorylation through targeting PPP2R2A in NSCLC cells and suggest that it may serve as a therapeutic target in NSCLC therapy. PMID: 23959478
    16. PPP2R2A status may serve as a marker to predict therapeutic efficacy to PARP inhibition. PMID: 23087057
    17. Both B55alpha and nuclear forkhead box O1 protein (FOXO1) levels are increased under hyperglycemic conditions in transgenic db/db mouse islets, an animal model of type 2 diabetes. PMID: 22417654
    18. These data demonstrate that B55alpha acts to antagonize Cyclin A/Cdk-dependent activation of FoxM1, to ensure that FoxM1 activity is restricted to the G(2) phase of the cell cycle. PMID: 21813648
    19. Somatic deletion rather than germline sequence variants of PPP2R2A may play a more important role in prostate cancer susceptibility. PMID: 21872824
    20. The interaction of human adenovirus E4orf4 with both Cdc55 and B55 involves residues within blades 1 and 2, a finding that is consistent with the idea that E4orf4 binding may block the dephosphorylation of at least some PP2A substrates. PMID: 21047956
    21. cyclin G2 also associates with various PP2A B' regulatory subunits, as previously shown for cyclin G1 PMID: 11956189
    22. CFTR is regulated by a direct interaction with the protein phosphatase 2A PMID: 16239222
    23. PP2A ABalphaC and ABdeltaC holoenzymes function as positive regulators of Raf1-MEK1/2-ERK1/2 signaling by targeting Raf1 PMID: 16239230
    24. hAR is a direct target of LEF-1/TCF transcriptional regulation in PCa cells; expression of the hAR protein is suppressed by a degradation pathway regulated by cross-talk of Wnt, Akt, and PP2A PMID: 16474850
    25. Bub1 targets PP2A to centromeres, which in turn maintains Sgo1 at centromeres by counteracting Plk1-mediated chromosome removal of Sgo1. PMID: 16580887
    26. deregulation of CHEK2 and/or PPP2R2A is of pathogenetic importance in at least a subset of germ cell tumors PMID: 16790090
    27. The scaffolding subunit exhibits considerable conformational flexibility, which is proposed to play an essential role in PP2A function. PMID: 17055435
    28. PP2A binding to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of FGFR stimulation PMID: 17255109
    29. Protein phosphatase 2A and separase form a complex regulated by separase autocleavage PMID: 17604273
    30. the protein phosphatase 2A regulatory subunit alpha4 has a novel role in the regulation of cell spreading and migration PMID: 17693407
    31. PP2A constitutively dephosphorylates the class IIa member HDAC7 to control its biological functions as a regulator of T cell apoptosis and endothelial cell functions. PMID: 18339811
    32. Homozygous deletions in a number of biologically important genes were found in prostate cancer cell lines, including PPP2R2A and BNIP3L identified in this study. PMID: 18670647
    33. These highly related members of the same subfamily of PP2A regulatory subunits differentially regulate TGF-beta/Activin/Nodal signalling to elicit opposing biological outcomes. PMID: 18697906
    34. The s show that E4orf4 protein interacts uniquely with B55 family subunits and that cell killing increases with the level of E4orf4 expression. PMID: 19535438
    35. The results suggest that PR55 alpha specifically regulates PP2A-mediated beta-catenin dephosphorylation and plays an essential role in Wnt signaling. PMID: 19556239

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  • 蛋白家族：
    Phosphatase 2A regulatory subunit B family
  • 组织特异性：
    Expressed in all tissues examined.
  • 数据库链接：

    HGNC: 9304

    OMIM: 604941

    KEGG: hsa:5520

    STRING: 9606.ENSP00000325074

    UniGene: Hs.146339