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PPP2R3A Antibody

  • 货号：
    CSB-PA925621
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA925621(PPP2R3A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA925621(PPP2R3A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T cells, PC3 cells, Primary antibody: CSB-PA925621(PPP2R3A Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q06190
  • 基因名：
  • 别名：
    AI118493 antibody; DNA for thyroid hormone receptor binding site (258bp) antibody; P2R3A_HUMAN antibody; PP2A subunit B B''-PR72/PR130 antibody; PP2A subunit B B72/B130 isoforms antibody; PP2A subunit B isoform PR72/PR130 antibody; PP2A subunit B isoform R3 isoform antibody; PP2A subunit B isoforms B''-PR72/PR130 antibody; PP2A subunit B isoforms B72/B130 antibody; PP2A subunit B PR72/PR130 isoforms antibody; PP2A subunit B R3 isoform antibody; PPP2R3 antibody; Ppp2r3a antibody; PR130 antibody; PR59 antibody; PR72 antibody; Protein phosphatase 2 (formerly 2A) regulatory subunit B'' alpha antibody; Serine/threonine protein phosphatase 2A 72/130 kDa regulatory subunit B antibody; Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B antibody; Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human PPP2R3A
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
  • 基因功能参考文献：
    1. HDAC1 and HDAC2 suppress the expression of PPP2R3A/PR130, a regulatory subunit of the trimeric serine/threonine phosphatase 2 (PP2A). PMID: 29472538
    2. this study shows the importance of PP2A complexes with the LIM domains of lipoma-preferred partner in cell adhesion and migration dynamics PMID: 26945059
    3. two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A demonstrating the ability or calcium ions to interact with and regulate PP2A PMID: 12524438
    4. The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A. PMID: 17535922
    5. PP2A can be targeted in a calcium-regulated manner to Cdc6 via the PR70 subunit, where it plays a role in regulating protein phosphorylation and stability. PMID: 18397887
    6. PR72 interacts physically and functionally with Naked cuticle. PR72, like Naked cuticle, acts as a negative regulator of the classical Wnt signaling cascade. PMID: 15687260

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  • 组织特异性：
    Expressed in heart, brain, placenta, lung, muscle and kidney.
  • 数据库链接：

    HGNC: 9307

    OMIM: 604944

    KEGG: hsa:5523

    STRING: 9606.ENSP00000264977

    UniGene: Hs.518155