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PPP3CB Antibody

  • 货号：
    CSB-PA018573GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P16298
  • 基因名：
  • 别名：
    Calcineurin A beta antibody; Calcineurin A2 antibody; Calcineurin B; formerly antibody; Calmodulin dependent calcineurin A subunit beta isoform antibody; Calmodulin-dependent calcineurin A subunit beta isoform antibody; CALNA 2 antibody; CALNA2 antibody; CALNB antibody; CAM PRP catalytic subunit antibody; CAM-PRP catalytic subunit antibody; CNA2 antibody; CnAbeta antibody; PP2BB_HUMAN antibody; PP2Bbeta antibody; PPP3CB antibody; Protein phosphatase 2B; catalytic subunit; beta isoform; formerly antibody; Protein phosphatase 3 (formerly 2B) catalytic subunit beta isoform antibody; Protein phosphatase 3 catalytic subunit beta isoform antibody; Protein phosphatase 3 catalytic subunit beta isozyme antibody; Serine/threonine protein phosphatase 2B catalytic subunit beta isoform antibody; Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PPP3CB
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32.
  • 基因功能参考文献：
    1. The mRNA expressions of PPP3CB and MEF2C were significantly up-regulated, and CAMK1 and PPP3R1 were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB, MEF2C and PLCE1 compared to aortic valve disease patients PMID: 27907007
    2. ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes are potential candidate genes for schizophrenia, especially in patients with deficits in sustained attention and executive function. PMID: 21531385
    3. The expression of a constitutively active Calcineurin stimulates myoblast differentiation, whereas a Calcineurin antisense has the opposite effect. PMID: 21664352
    4. A novel-splicing variant of calcineurin Ass CnAss-FK, which is encoded by an intron-retaining mRNA and is deficient in the autoinhibitory domain, is predominantly expressed in mature follicular keratinocytes. PMID: 21423799
    5. [review] The nuclear localization sequence, a region spanning amino acids 172-183 of calcineurin A beta, is essential for recognition and shuttling of calcineurin into the nucleus by importin beta. PMID: 19925438
    6. calcineurin regulates AUF1 posttranslationally in vitro and PTH gene expression in vivo but still allows its physiological regulation by calcium and phosphate PMID: 15514034
    7. depressed NCX activity might contribute to the etiology of in vivo cardiac hypertrophy and dysfunction occurring under conditions in which both calcineurin and protein kinase C are chronically activated PMID: 15557343
    8. Calcineurin A beta expression is an additional means of regulating calcineurin activity in the heart. PMID: 16024800
    9. Data show that the calcineurin pathway is activated in hypertrophic myocardium as demonstrated by increased calcineurin activity and expression of calcineurin A-beta and B, and GATA-4, and a shift of cytoplasmic NFAT-3 into the nucleus. PMID: 18034994
    10. We describe a case of Calcineurin inhibitor-mediated bilateral hippocampal injury after bone marrow transplantation. PMID: 18458866
    11. TAK1-TAB1-TAB2 selectively induces calcineurin-NFAT signalling through direct phosphorylation of RCAN1, while calcineurin activation diminishes TAK1 signalling by dephosphorylation of TAK1 and TAB1. PMID: 19136967
    12. calcineurin is inhibited by cyclosporine A, which then exerts multiple effects on human melanoma cell lines HT168 and WM35 PMID: 19287956
    13. calcineurin can dephosphorylate GSK-3beta at Ser-9 and form a stable complex with GSK-3beta, suggesting the possibility that calcineurin regulates the dephosphorylation and activation of GSK-3betain vivo PMID: 19659461

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    PPP phosphatase family, PP-2B subfamily
  • 数据库链接：

    HGNC: 9315

    OMIM: 114106

    KEGG: hsa:5532

    STRING: 9606.ENSP00000378306

    UniGene: Hs.500067