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PPRC1 Antibody

  • 货号：
    CSB-PA008323
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q5VV67
  • 基因名：
    PPRC1
  • 别名：
    PPRC1 antibody; KIAA0595 antibody; Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 antibody; PGC-1-related coactivator antibody; PRC antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human PRC.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.
  • 基因功能参考文献：
    1. PRC and c-MYC can act in concert through Akt-GSK-3 signaling to reprogram gene expression in response to mitochondrial stress. PMID: 27789709
    2. PRC is a negative regulator of endothelial inflammation; it negatively regulates endothelial adhesion of monocytes via inhibition of NF kappaB activity PMID: 23954632
    3. A general role for PRC in the adaptive response to cellular dysfunction. PMID: 23364789
    4. PRC has a role in the rapid modulation of metabolic functions in response to the status of the cell cycle PMID: 19956726
    5. overexpression of the PRC pathway is responsible for mitochondrial proliferation in the context of thyroid oncocytoma PMID: 14550271
    6. PGC-1 has a role in regulating gluconeogenic genes along with HNF-4alpha and SREBP-1 PMID: 14722127
    7. This review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure. PMID: 16511594
    8. Upregulation of PGC-1alpha and PGC-1beta in the colorectal tumor cells can be part of an adaptation mechanism to help overcome the severe consequences of mtDNA mutations on oxidative phosphorylation. PMID: 17341490
    9. These results revealed that bile acid inhibits the promoter activity of PGC-1 in an SHP-dependent manner. PMID: 17390079
    10. Activation of the SIRT1/PGC-1 pathway, in a metabolic context promotes mitochondrial function and this pathway plays a role in neurodegerative disease. Review. PMID: 17937892
    11. The results are consistent with a pathway whereby PRC regulates NRF-2-dependent genes through a multiprotein complex involving HCF-1. PMID: 18343819
    12. support a role for PRC in the integration of pathways directing mitochondrial respiratory function and cell growth PMID: 19036724
    13. Coordinate regulation of nucleus-encoded mitochondrial transcription factors by NRFs and PGC-1 family coactivators is essential to the control of mitochondrial biogenesis PMID: 15684387

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors.
  • 数据库链接：

    HGNC: 30025

    OMIM: 617462

    KEGG: hsa:23082

    STRING: 9606.ENSP00000278070

    UniGene: Hs.533551