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PRCP Antibody

  • 货号：
    CSB-PA921139
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA921139(PRCP Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA921139(PRCP Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane 1-3: SKOV3 cells, A549 cells, human liver cancer tissue, Primary antibody: CSB-PA921139(PRCP Antibody) at dilution 1/100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
  • 其他：

产品详情

  • Uniprot No.：
    P42785
  • 基因名：
  • 别名：
    Angiotensinase C antibody; HUMPCP antibody; Lysosomal carboxypeptidase C antibody; Lysosomal Pro X carboxypeptidase antibody; Lysosomal Pro-X carboxypeptidase antibody; MGC2202 antibody; PCP antibody; PCP_HUMAN antibody; PRCP antibody; Proline carboxypeptidase antibody; Prolylcarboxypeptidase (angiotensinase C) antibody; Prolylcarboxypeptidase antibody; prolylcarboxypeptidase isoform 1 preproprotein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human PRCP
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
  • 基因功能参考文献：
    1. For the first time, PRCP is identified as an apelin-cleaving enzyme. PMID: 27449720
    2. The decrease in PRCP levels in the first 24 h after stroke onset is associated with stroke severity and an unfavourable short-term stroke outcome PMID: 25370794
    3. PRCP1 interacts with plasma kallikrein (PK) at multiple sites for PK activation. PMID: 25324000
    4. The present results indicated PRCP rs7104980 can be considered as a marker for EH and Hap3 GAGCACTAACA (PRCP) and Hap16 TTTA (CMA1) might be associated with essential hypertension in Chinese Han population. PMID: 22679278
    5. PRCP regulates cell growth, angiogenesis, and the response to vascular injury PMID: 23744584
    6. analysis of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors PMID: 22079761
    7. PRCP as a resistance factor for 4OHTAM resistance in estrogen receptor-positive breast cancer cells. PMID: 21087932
    8. A single peptide, with the sequence YPRPIHPA, as a novel substrate for PRCP in human cerebrospinal fluid. PMID: 20517885
    9. Purified PrCP yielded crystals belonging to space group R32, with unit-cell parameters a = b = 181.14, c = 240.13 A, that diffracted to better than 2.8 A resolution. PMID: 20516604
    10. A structure-based alignment with the previously undescribed structure of DPP7 illuminates the mechanism of orthogonal substrate specificity of PRCP and DPP7. PMID: 20540760
    11. Data suggest that the E112D polymorphism in the PRCP gene may be a useful genetic marker to predict the antihypertensive effect of short-term benazepril treatment in hypertensive patients. PMID: 20079160
    12. PRCP appears to be a HUVEC-associated prekallikrein activator. PMID: 11830581
    13. Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator. PMID: 12123826
    14. recombinant protein, identical to enzyme from human umbilical vein endothelial cells, is a prekallikrein activator. PMID: 14996700
    15. Prolylcarboxypepdiase E112D (rs2298668)D allele alone and jointly with chronic hypertension were associated with a significantly increased risk of preeclampsia PMID: 16681991
    16. role in regulation cardiovascular tone; proinflammatory agent PMID: 18396440
    17. These investigations showed that the C-terminal region of the rPRCP(40) contributes to PRCP's catalytic function, and provided additional experimental evidence for this suggestion. PMID: 18656443

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  • 亚细胞定位：
    Lysosome.
  • 蛋白家族：
    Peptidase S28 family
  • 组织特异性：
    Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney.
  • 数据库链接：

    HGNC: 9344

    OMIM: 176785

    KEGG: hsa:5547

    STRING: 9606.ENSP00000377055

    UniGene: Hs.523936