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PRDM2 Antibody

  • 货号：
    CSB-PA921106
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA921106(PRDM2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA921106(PRDM2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q13029
  • 基因名：
    PRDM2
  • 别名：
    GATA-3-binding protein G3B antibody; HUMHOXY1 antibody; KMT8 antibody; Lysine N-methyltransferase 8 antibody; MTB-ZF antibody; MTE-binding protein antibody; PR domain containing 2; with ZNF domain antibody; PR domain zinc finger protein 2 antibody; PR domain-containing protein 2 antibody; PRDM2 antibody; PRDM2_HUMAN antibody; Retinoblastoma protein binding zinc finger protein antibody; Retinoblastoma protein-interacting zinc finger protein antibody; Retinoblastoma protein-interacting zinc-finger protein antibody; RIZ antibody; RIZ1 antibody; RIZ2 antibody; Zinc finger DNA binding protein antibody; Zinc finger protein RIZ antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human PRDM2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.
  • 基因功能参考文献：
    1. The s have found that overexpression of RIZ1 in HEK293 cells reduced the expression of Akt3 protein. PMID: 29367689
    2. Promoter hypermethylation may play an important role in the epigenetic silencing of RIZ1 expression in human glioma tissues and glioblastoma cell lines. PMID: 27757741
    3. the Pro704 p-/- allele of RIZ is significantly more common in CML patients with Loss of hematological response than good responders (p = .001). We showed that LOH p-/- homozygosity of RIZ1 was common event in BC than proline p+/+ homozygosity and proline p+/+ homozygosity more common feature in CP phase CML. PMID: 27830966
    4. Promoter region methylation of RIZ1 may play an important role in the epigenetic silencing of RIZ1 expression in pituitary adenomas, which may translate into important diagnostic and therapeutic applications PMID: 28718376
    5. RIZ1 expression is negatively correlated with glioma differentiation and can serve as a predictor of glioma prognosis and thus could be a potential therapeutic target for patients with gliomas. PMID: 26690953
    6. Loss of RIZ1 expression due to methylation is associated with Renal Cell Carcinoma. PMID: 25987089
    7. PRDM2 downregulation may play a role in dopamine-agonist resistance and tumor recurrence in prolactinomas. PMID: 25884948
    8. Results suggest that high expression of SMYD3 is related to the occurrence of esophageal squamous cell carcinoma. Also, its suppression promoted the expression of RIZ1 suggesting a signal transduction pathway between SMYD3 and RIZ1. PMID: 24993551
    9. PRDM2, PRDM5, PRDM16 promoters are methylated and their expression is suppressed in lung cancer cells. PMID: 24966940
    10. The development and progression of esophageal squamous cell carcinoma are related to the inactivation of RIZ1. PMID: 24115813
    11. RIZ1 expression is significantly downregulated as the formation of meningiomas progressed, and suggest that RIZ1 may represent a promising candidate tumor suppressor gene that contributes to malignant meningiomas. PMID: 22614009
    12. Reduction of RIZ1 expression aggravates the progression of liver fluke-related cholangiocarcinoma PMID: 23098508
    13. Aberrant methylation and decreased expression of the RIZ1 gene are frequent in adult acute lymphoblastic leukemia of T-cell phenotype PMID: 22300346
    14. Data suggest that promoter methylation may play an important role in the epigenetic silencing of RIZ1 gene expression in human esophageal squamous cell carcinoma. PMID: 22363126
    15. Acting as a negative regulator of RIZ1 function, PRFM2 mediates effect of cell proliferation by estrogen via regulation of cell survival and differentiating gene expression. PMID: 21503890
    16. RIZ1 may be a potential tumor suppressor in human esophageal squamous cell cancer. PMID: 22372344
    17. RIZ1 might play an important role in tumor metastasis, and the PR domain alone possessed anticancer activity. PMID: 21369371
    18. Results suggest that the RIZ1 gene is inactivated in MDS and AML in part by methylation, whereas another mechanism should be involved in others. PMID: 20828818
    19. promoter methylation and H3K9 modifications work together to silence the RIZ1 gene in hepatocellular carcinoma (HCC). PMID: 20675009
    20. RIZ1 promoter methylation is not a common event in neuroblastoma. PMID: 20878080
    21. RIZ1 negatively regulated the cell proliferation of monocytic leukemia cells via activation of p53. PMID: 20594067
    22. Loss of RIZ1 expression will lead to an increase in myeloid blast cell population resulting in CML progression. PMID: 19602237
    23. Reduced expression of RIZ1 may play an important role in the pathogenesis and/or development of cervical cancer, and is considered to be caused in part by aberrant DNA methylation PMID: 20159667
    24. loss of RIZ1 mRNA in human cancers is associated with DNA methylation of its promoter CpG island. PMID: 11719434
    25. These findings suggest that RIZ may be a possible target of structural alteration leading to leukemia. PMID: 12002276
    26. Frameshift mutations of RIZ, but no point mutations, were found in RIZ1 exons in malignant melanomas with deletions in 1p36. RIZ has potential role in the multi-step tumor forming process of malignant melanoma of the skin. PMID: 12082534
    27. RIZ1 in gastric neoplasms undergoes biallelic inactivation. PMID: 14534544
    28. Tumor suppressor RIZ1 (PRDM2) methylates histone H3 on lysine 9, and this activity is reduced by mutations in the PR domain found in human cancers. PMID: 14633678
    29. Frameshift mutations of RIZ may play an important role in gastric cancers with microsatellite instability. PMID: 15309726
    30. the presented results indicated that the Zn-finger domain could be endowed with the putative oncogenic activity of RIZ2 gene product. PMID: 15488642
    31. RIZ1 may be a new candidate gene for involvement in the variation seen in bone mineral density. PMID: 15579774
    32. recurrent inactivation of the tumour suppressor RIZ1 suggests that this event may be a significant contributing factor to tumour development in pheochromocytomas and abdominal paragangliomas PMID: 15809732
    33. Forced RIZ1 expression in CML-BC cell lines decreases IGF-1 receptor activation and activation of downstream signaling components extracellular signal-regulated kinase 1/2 and AKT PMID: 16953217
    34. The current study suggested an important role for RIZ1 expression in thyroid tumorigenesis. PMID: 17103461
    35. A563G variant not found in diffuse large B-cell lymphomas. PMID: 17205536
    36. the ERalpha cofactor RIZ gene has a prominent effect on bone marrow density(BMD), and the P704 genotype modulates the impact of estradiol on BMD PMID: 17356055
    37. RIZ polymorphisms may be important predictive markers for lung cancer susceptibility. PMID: 17693662
    38. Reduced expression of RIZ1 may play an important role in the pathogenesis and/or development of epithelial ovarian carcinoma, and is considered to be caused in part by aberrant DNA methylation. PMID: 17922684
    39. The proliferation, migration induction and apoptosis inhibition activities of SMYD3 in hepatocellular carcinoma may be mediated through RIZ1 CpG promoter hypermethylation. PMID: 17963297
    40. observed no association of the RIZ1 Pro704 insertion-deletion polymorphism with BMD or fracture risk PMID: 18037365
    41. Results suggest that the inactivation of the RIZ1 by DNA methylation at its promoter region is involved in the tumorigenesis of hepatocellular carcinoma, particularly in the early stage of disease. PMID: 18712668
    42. methyl-balanced diet conferred additional survival benefits compared to a tumor-inducing methyl-imbalanced diet only in mice with wild type RIZ1 but not in mice deficient in RIZ1 PMID: 18852888
    43. RIZ1 is expressed in normal prostate epithelial cells and down-regulated in cancer cells, with a switch of its localization from the nucleus to the cytoplasm upon cancer grade progression. RIZ1 levels were modulated by DHT or E2 treatment in vitro. PMID: 19746436

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily
  • 组织特异性：
    Highly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3.
  • 数据库链接：

    HGNC: 9347

    OMIM: 601196

    KEGG: hsa:7799

    STRING: 9606.ENSP00000235372

    UniGene: Hs.371823