PRMT7 Antibody
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货号:CSB-PA559119
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规格:¥1100
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图片:
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其他:
产品详情
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Uniprot No.:Q9NVM4
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基因名:PRMT7
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别名:[Myelin basic protein]-arginine N-methyltransferase PRMT7 antibody; ANM7_HUMAN antibody; FLJ10640 antibody; Histone-arginine N-methyltransferase PRMT7 antibody; KIAA1933 antibody; Myelin basic protein arginine N methyltransferase antibody; OTTHUMP00000174863 antibody; PRMT7 antibody; Protein arginine methyltransferase 7 antibody; Protein arginine N-methyltransferase 7 antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Fusion protein of Human PRMT7
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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抗体亚型:IgG
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纯化方式:Antigen affinity purification
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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产品提供形式:Liquid
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应用范围:ELISA,WB
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推荐稀释比:
Application Recommended Dilution ELISA 1:1000-1:2000 WB 1:200-1:1000 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 impr...显示更多
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基因功能参考文献:
- These kinetic studies suggest a biochemical explanation for the interplay between PRMT5- and PRMT7-mediated methylation of the same substrate at different residues and also suggest a general model for regulation of PRMTs. PMID: 28874563
- The s showed that ASS1 mutations linked to type I citrullinemia disrupt the ASS1-PRMT7 interaction, which might explain the molecular pathogenesis of the disease. PMID: 28587924
- Loss of PRMT7 causes decreases in arginine methylation throughout the proteome.Loss of the arginine methyltranserase PRMT7 causes syndromic intellectual disability with microcephaly and brachydactyly. PMID: 27718516
- Upregulation of PRMT7 in breast cancer may have a significant role in promoting cell invasion through the regulation of MMP9. PMID: 25605249
- results define PRMT7 as an inducer of breast cancer metastasis and present the opportunity for applying PRMT7-targeted therapeutics to treat highly invasive breast cancers PMID: 25136067
- Data indicate that two acidic residues within the double E loop, Asp-147 and Glu-149, confer specificity to protein arginine methyltransferase 7 (PRMT7. PMID: 25294873
- reducing expression of individual PRMT7 target DNA repair genes showed that only the catalytic subunit of DNA polymerase, POLD1, was able to resensitize PRMT7 knock-down cells to DNA-damaging agents. PMID: 22761421
- Human protein arginine methyltransferase 7 (PRMT7) is a type III enzyme forming omega-NG-monomethylated arginine residues. PMID: 22241471
- Here the s report that H3R2 is also symmetrically dimethylated (H3R2me2s) by PRMT5 and PRMT7 and present in euchromatic regions. PMID: 22231400
- both domains are required for functionality PMID: 15044439
- PRMT7 (like PRMT5) is a Type II methyltransferase capable of producing symmetric dimethylarginine modifications in proteins. PMID: 15494416
- that in human cells, PRMT5 and PRMT7 are required for Sm protein sDMA modification, and that Sm protein symmetric dimethylarginine modification is required for snRNP biogenesis in human cells. PMID: 17709427
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相关疾病:Short stature, brachydactyly, intellectual developmental disability, and seizures (SBIDDS)
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亚细胞定位:Cytoplasm, cytosol. Nucleus.
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蛋白家族:Class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family, PRMT7 subfamily
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数据库链接:
HGNC: 25557
OMIM: 610087
KEGG: hsa:54496
STRING: 9606.ENSP00000343103
UniGene: Hs.640229