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PRND Antibody

  • 货号：
    CSB-PA890741ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA890741ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PRND Polyclonal antibody
  • Uniprot No.：
    Q9UKY0
  • 基因名：
    PRND
  • 别名：
    dJ1068H6.4 antibody; DPL antibody; Dublet antibody; MGC41841 antibody; Prion gene complex downstream antibody; Prion like protein doppel antibody; Prion protein 2 (dublet) antibody; Prion protein 2 antibody; Prion-like protein doppel antibody; PRND antibody; PRND_HUMAN antibody; PrPLP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Prion-like protein doppel protein (20-160AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for normal acrosome reaction and for normal male fertility. Can bind Cu(2+).
  • 基因功能参考文献：
    1. results demonstrate that blocking doppel can control VEGF signaling in TECs and selectively inhibit tumor angiogenesis. PMID: 26950422
    2. The association between the APOE, CYP46, PRNP and PRND genes and the profile of neuropsychiatric symptoms in Polish subjects with Alzheimer's disease and mild cognitive impairment, was evaluated. PMID: 22453181
    3. in astrocytomas, Dpl undergoes different molecular processes that might constitute additional helpful tools to characterize the glial tumor progression PMID: 20981146
    4. Cytotoxicity induced by the expression of Dpl and truncated PrP in neural derived cells are closely related with the apoptosis process. PMID: 19728151
    5. expression pattern and biochemical characteristics in human tissues and in Chinese hamster ovary cells transfected with wild-type or variant human Dpl gene constructs PMID: 12200435
    6. Doppel expression is not modified in the brains of patients with Creutzfeldt-Jakob disease. PMID: 12586339
    7. human Doppel fails to interact with itself; Dpl and PrP are not related or are only marginally related with respect to their ligand binding behaviour PMID: 15158907
    8. results demonstrate that Doppel and PrPc co-patch extensively at the plasma membrane PMID: 15203115
    9. Doppel interacts with the full-length laminin receptor precursor protein PMID: 15246873
    10. Doppel is expressed early during ontogenesis, and is found in both germ cells and Sertoli cells. Doppel may play a physiological role in acrosome biogenesis. PMID: 16421231
    11. Extensive differences in PRND gene expression were also found within each grade of malignancy, suggesting that PRND mRNA quantitation might be useful to distinguish astrocytoma subtypes. PMID: 17390034
    12. Study provides the foundation for further study of Dpl biological functions in vitro and in vivo. PMID: 17894227
    13. Results might suggest a potential and functional role for Dpl in tumor cells migratory and morphological behaviours and address to future gene-targeted therapeutic interventions. PMID: 18936526
    14. results suggested that the function of Dpl is antagonistic to PrP rather than synergistic PMID: 19129949

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Prion family
  • 组织特异性：
    Expressed in testis, in Sertoli cells, ejaculated spermatozoa and in seminal fluid (at protein level).
  • 数据库链接：

    HGNC: 15748

    OMIM: 604263

    KEGG: hsa:23627

    STRING: 9606.ENSP00000306900

    UniGene: Hs.406696