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PROS1 Antibody

  • 货号：
    CSB-PA018754LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA018754LA01HU diluted at 1:200 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA018754LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA018754LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PROS1 Polyclonal antibody
  • Uniprot No.：
    P07225
  • 基因名：
  • 别名：
    Preproprotein S antibody; Propiece of latent protein S antibody; PROS 1 antibody; PROS antibody; PROS_HUMAN antibody; proS1 antibody; Protein S alpha antibody; Protein Sa antibody; PS 21 antibody; PS 22 antibody; PS 23 antibody; PS 24 antibody; PS 25 antibody; PS 26 antibody; PS21 antibody; PS22 antibody; PS23 antibody; PS24 antibody; PS25 antibody; PS26 antibody; PSA antibody; THPH5 antibody; THPH6 antibody; Vitamin K dependent protein S antibody; Vitamin K-dependent plasma protein S antibody; Vitamin K-dependent protein S antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Vitamin K-dependent protein S protein (42-676AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PROS1 Antibody (CSB-PA018754LA01HU)，的标记方式是Non-conjugated。对于PROS1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA018754LB01HU PROS1 Antibody, HRP conjugated ELISA
    FITC CSB-PA018754LC01HU PROS1 Antibody, FITC conjugated
    Biotin CSB-PA018754LD01HU PROS1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
  • 基因功能参考文献：
    1. The s provide strong evidence that the rare Protein S Heerlen (PSH) mutation variant is associated with venous thrombosis in unselected individuals. PMID: 28374852
    2. Functional PROS1 variants are more common in the general Swedish population than anticipated. PMID: 29883906
    3. The present case combined with the review of the literature suggests that p.Arg451* in the PROS1 gene mainly leads to clinically evident thrombosis following trauma, surgery or serious comorbidities especially malignancy. PMID: 29321366
    4. Protein S and Gas6 mediates phagocytosis of HIV-1-infected cells by bridging receptor tyrosine kinase Mer to phosphatidylserine exposed on infected cells. PMID: 29304470
    5. these results suggest a novel pathogenic role of SPE B that initiates protein S degradation followed by the inhibition of apoptotic cell clearance by macrophages PMID: 27181595
    6. Taken together, our gain-of-function, loss-of-function analyses suggest that PROS may facilitate cell proliferation and promote castration resistance in human castration-resistant PCa-like cells via its apoptosis-regulating property. PMID: 27342144
    7. protein S has a clinical relevance and a protective role in pulmonary fibrosis PMID: 27172994
    8. Due to the versatility exemplified, this probe holds great promise for exploring the role of protein S-nitrosylation in the pathophysiological process of a variety of vascular diseases PMID: 28284075
    9. There was no association between PS-Tokushima and recurrent pregnancy loss and a PS deficiency or low PS activity was shown not to serve as a reliable clinical predictor of subsequent miscarriage. PMID: 28214760
    10. we identify PROS1 as a driver of Oral Squamous Cell Carcinoma tumor growth and a modulator of AXL expression PMID: 28118606
    11. The prevalence of PS de fi ciency in the present study was higher than in Western countries and con fi rms the high prevalence of PS de fi ciency in Asian populations PMID: 27748013
    12. Patients with type 2 diabetes had significantly lower circulating free protein S than healthy control subjects PMID: 27207541
    13. In the present study, gene analysis of six unrelated Japanese families diagnosed with congenital protein S deficiency identified five missense mutations in the PROS1 gene - c.757C>T (Ala139Val; A139V), c.1346 G>T (Cys449Phe; C449F), c.1352G>A (Arg451Gln; R451Q), c.1424G>T (Cys475Phe; C475F) and c.1574C>T (Ala525Val; A525V) - and one frameshift mutation, c.2135delA (Asp599ThrfsTer13; D599TfsTer13). PMID: 28088608
    14. The odds ratio of developing idiopathic fatal pulmonary embolism as a variant carrier for PROS1 is 56.4 (95% CI, 5.3-351.1; P = 0.001). PMID: 28174134
    15. described a novel PROS1 frameshift mutation, c.74dupA, in a hereditary protein S deficiency family. Interestingly, both of the proband and his mother carried the mutation and had a protein S deficiency, however, only the proband suffered a pulmonary embolism while his mother had no history of any thrombosis, suggesting that a triggering event might have been involved in the thrombus formation. PMID: 27846449
    16. PROS1 may play an important role in the development of glioblastoma multiforme through cellular proliferation, migration and invasion as well as apoptosis. PMID: 27840905
    17. Low protein S expression is associated with diabetes mellitus. PMID: 27345772
    18. analysis of genotype phenotype correlation in PROS1 in a large cohort of adults with suspicion of inherited quantitative protein S deficiency PMID: 26466767
    19. The immunoabsorption of PON1 from plasma significantly reduced protein S anti-coagulant activity. PMID: 26358807
    20. Elevated levels of circulating microparticles can play a role in carriers of mild and severe inherited thrombophilia resulting from protein S deficiency. PMID: 26354831
    21. The ELISA system using the PS K196E mutation-specific antibody is a useful tool for the rapid identification of PS K196E carriers, who are at a higher risk for venous thromboembolism. PMID: 26186226
    22. A PROS1 c.1486_1490delGATTA mutation on exon 12. appeared to be the primary cause of thrombosis in the family of the present study. PMID: 25997409
    23. analysis of the amino acid residues in the laminin G domains of protein S involved in tissue factor pathway inhibitor interaction PMID: 25716664
    24. Women with low levels of plasma PS activity and free PS during early pregnancy might have increased risks of pregnancy-induced hypertension, or pre-eclampsia. PMID: 25879167
    25. analysis of compound heterozygote protein S deficiency in two Japanese patients [case reports] PMID: 25868595
    26. Protein S exacerbates acute alcoholic hepatitis by inhibiting apoptosis of activated natural killer T cells. PMID: 25399514
    27. The present study highlights that the GAS6/ProS-TAM system correlates in several ways with disease activity in systemic lupus erythematosus PMID: 23497733
    28. genetic polymorphism affects endogenous thrombin potential among FV Leiden carriers PMID: 24226152
    29. Identical large duplication mutation of PROS1 was detected in 3 unrelated patients with thrombophilia from hereditary protein S deficiency. PMID: 24992033
    30. Anti-human protein S antibody induces tissue factor expression through a direct interaction with PFKP and ERK1/2 activation in coronary artery endothelial cells. PMID: 24331211
    31. Data indicate that the protein S sex hormone-binding globulin (SHBG)-like domain was important for binding and enhancement of tissue factor pathway inhibitor (TFPI). PMID: 24740810
    32. study found the S K196E mutation, a genetic risk factor for venous thromboembolism, was not found in Chinese or Koreans; results suggest the protein S K196E mutation is a recent occurrence and fixed within the Japanese population PMID: 23721692
    33. implicate protein S residues 37-50 as a binding site for FVa that mediates, at least in part, the direct inhibition of FVa-dependent procoagulant activity by protein S PMID: 23892573
    34. miR-494 is involved in the mechanism of estrogen-mediated downregulation of PS expression PMID: 23789915
    35. This is the first report of a large deletion of PROS1 from exon 1 through 12 in Polish patients with deep-vein thrombosis. PMID: 23473639
    36. PS exerts anticoagulant cofactor activity with TFPIalpha from any physiological pool, likely by localizing TFPIalpha to membrane surfaces, stabilizing its interaction with membrane-bound FXa, and slowing thrombin generation. PMID: 24233490
    37. Data suggest that protein S testing and PROS1 testing should not be considered in unselected patients with venous thrombosis. PMID: 24014240
    38. This study is the largest investigation of ProS deficiency in China and the first investigation of the influence of Type I ProS missense mutations on the global level of coagulation function. PMID: 23813890
    39. The effect of oral contraceptives on TFPI and PS is a possible explanation for the increased risk of venous thrombosis associated with oral contraceptives. PMID: 23407778
    40. Data indicate that activated T cells express Pros1. PMID: 23850380
    41. Platelet protein S may be an essential pool of protein S that counterbalances procoagulant activities on platelets. PMID: 23238804
    42. sputum glutaredoxin-1 may have a role in asthma, while protein S may have a role in better lung function PMID: 23370801
    43. The tyrosine kinase receptor MER is activated by PROS and mediates its inhibitory effect on VEGF-A-induced EC proliferation. PMID: 23065156
    44. TFPI Kunitz domain 3 residue Glu226 is essential for TFPI enhancement by protein S. PMID: 23074276
    45. PROS1 is elevated in high grade and castration-resistant prostate cancer and could serve as a potential biomarker of aggressive disease. PMID: 22908226
    46. mutation deletions but no other types of rearrangements detected in patients with protein S deficiency PMID: 22627709
    47. genetic polymorphism is associated with increased free plasma tissue factor pathway inhibitor levels PMID: 22273984
    48. proteolytic cleavage is increased in patients with essential thrombocythaemia and reduced in patients with chemotherapy-induced thrombocytopenia PMID: 22318644
    49. Serum of women during third trimester of pregnancy complicated by intrauterine growth restriction (IUGR) had significantly lower functional and free protein S compared with control; however, no correlation was found between total protein S and IUGR. PMID: 22104477
    50. Persistently low protein S activity levels are highly indicative of a genetic alteration in PROS1. PMID: 22261441

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  • 相关疾病：
    Thrombophilia due to protein S deficiency, autosomal dominant (THPH5); Thrombophilia due to protein S deficiency, autosomal recessive (THPH6)
  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Plasma.
  • 数据库链接：

    HGNC: 9456

    OMIM: 176880

    KEGG: hsa:5627

    STRING: 9606.ENSP00000377783

    UniGene: Hs.64016