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PRPF18 Antibody

  • 货号：
    CSB-PA003856
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HuvEc cells using PRPF18 Polyclonal Antibody
    • Western Blot analysis of K562 NIH-3T3 cells using PRPF18 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q99633
  • 基因名：
    PRPF18
  • 别名：
    PRPF18 antibody; HPRP18Pre-mRNA-splicing factor 18 antibody; PRP18 homolog antibody; hPRP18 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PRPF18.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Participates in the second step of pre-mRNA splicing.
  • 基因功能参考文献：
    1. These results validated the association of two previously known skin pigmentation genes, SLC24A5 (minimum p = 2.62 x 10(-14), rs1426654) and SLC45A2 (minimum p = 9.71 x 10(-10), rs16891982), and revealed the intergenic region of BEND7 and PRPF18 as a novel locus associated with this trait (minimum p = 4.58 x 10(-9), rs6602666). PMID: 28300201
    2. We identified the pre-mRNA processing factor Prp18 as a stimulatory factor for influenza virus RNA synthesis. Prp18 facilitates the elongation reaction of viral polymerases by preventing the deleterious annealing of newly synthesized RNA to the template. Prp18 functions as a chaperone for NP to stimulate the formation of NP-RNA complexes. PMID: 27852861
    3. Presented is solution structure of the splicing factor motif of hPrp18, which forms a compact fold with two a helices interacting head-to-tail and a fixed linker loop. PMID: 22213562
  • 亚细胞定位：
    Nucleus speckle.
  • 蛋白家族：
    PRP18 family
  • 数据库链接：

    HGNC: 17351

    OMIM: 604993

    KEGG: hsa:8559

    STRING: 9606.ENSP00000367835

    UniGene: Hs.660649