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  4. PRSS50 Antibody

PRSS50 Antibody

  • 中文名称：
    PRSS50兔多克隆抗体
  • 货号：
    CSB-PA567041
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA567041(PRSS50 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA567041(PRSS50 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hepg2 cells, Primary antibody: CSB-PA567041(PRSS50 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q9UI38
  • 基因名：
    PRSS50
  • 别名：
    Cancer/testis antigen 20 antibody; CT 20 antibody; CT20 antibody; Probable threonine protease PRSS50 antibody; PRSS50 antibody; Serine protease 50 antibody; Testes specific protease 50 antibody; Testis specific protease like protein 50 antibody; Testis-specific protease-like protein 50 antibody; TSP 50 antibody; TSP50_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human PRSS50
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in proteolysis through its threonine endopeptidase activity.
  • 基因功能参考文献：
    1. TSP50 promotes the proliferation, migration and invasion of gastric cancer cells involving NF-kappaB dependent EMT activation. Targeting TSP50 may provide a novel therapeutic strategy for the management of gastric cancer PMID: 29361914
    2. human epidermal growth factor receptor 2 (HER-2) levels, were correlated well with TSP50/p-Samd2/3 and TSP50/p27 expression status. Thus, our studies revealed a novel regulatory mechanism underlying TSP50-induced cell proliferation and provided a new favorable intervention target for the treatment of breast cancer PMID: 28650473
    3. In patients with Colon cancer, the expression of TSP50 gene was associated with a poor prognosis. PMID: 28631709
    4. TSP50 plays a significant role in NSCLC cell proliferation and may act as a novel oncogene in the development and progression of NSCLC. PMID: 27109614
    5. Results suggest that 7P3A, which consists of 70 % 25-methoxyl-dammarane-3beta, 12beta, 20-triol and 30 % artemisinin, exhibits anti-cancer effects, in part, through downregulation of testes-specific protease 50 (TSP50) expression. PMID: 27039397
    6. Results show that TSP50 is up-regulated in laryngocarcinoma tumour tissues and its down-regulation inhibits cell proliferation, reduces cell migration and induces cell apoptosis of laryngocarcinoma in NF-KB mediated pathway. PMID: 25399078
    7. we found that some breast cancer diagnosis-associated features such as tumor size, tumor grade, estrogen receptors (ER) and progesterone receptors (PR) levels, were correlated well with TSP50/p65 and TSP50/MMP9 expression status PMID: 25811800
    8. TSP50's threonine protease activity is crucial for its effects on tumor formation. PMID: 25312478
    9. The mutations in the catalytic triad of TSP50 could significantly depressed TSP50-mediated cell proliferation and tumor formation. PMID: 25049081
    10. High TSP50 expression is associated with laryngocarcinoma. PMID: 25077921
    11. the importance of threonine 310, the most critical protease catalytic site in TSP50, to TSP50-induced cell proliferation and tumor formation PMID: 22574111
    12. TSP50 is a potential effective indicator of poor survival for colorectal carcinoma patients, especially for those with early-stage tumors. PMID: 21765952
    13. Results strongly suggest that bFGF mediates TSP50 downregulation by ERK1/2 activation, leading to the phosphorylation of Sp1 in this process. PMID: 20506264
    14. TSP50, a possible protease in human testes, is activated in breast cancer epithelial cells. PMID: 11782390
    15. TSP50 was largely downregulated in all testicular germ cell tumors. It may function in mammalian spermatogenesis. Its linear catalytic structure is similar to many serine proteases, except for a Thr-for-Ser residual catalytic site substitution. PMID: 15491742
    16. Overexpression of Sp1 and C/EBPbeta transcriptional factors upregulated the activities of the TSP50 promoter. PMID: 18462069
    17. These findings suggested that DNA methylation might regulate the TSP50 and mTSP50 gene expressions in different types of tissues and spermatic cells. PMID: 18662669

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  • 亚细胞定位：
    Endoplasmic reticulum. Note=May also localize to cytoplasmic membranes.
  • 蛋白家族：
    Peptidase S1 family
  • 组织特异性：
    Testis specific. Differentially expressed in some breast cancer tissues.
  • 数据库链接：

    HGNC: 17910

    OMIM: 607950

    KEGG: hsa:29122

    STRING: 9606.ENSP00000326598

    UniGene: Hs.120365