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PSD Antibody

  • 货号：
    CSB-PA018842LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate
      All lanes: PSD antibody at 3.2µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 110, 71 kDa
      Observed band size: 110 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA018842LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA018842LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PSD Polyclonal antibody
  • Uniprot No.：
    A5PKW4
  • 基因名：
  • 别名：
    PSD antibody; EFA6 antibody; EFA6A antibody; KIAA2011 antibody; PSD1 antibody; TYL antibody; PH and SEC7 domain-containing protein 1 antibody; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 antibody; Exchange factor for ARF6 antibody; Exchange factor for ARF6 A antibody; Pleckstrin homology and SEC7 domain-containing protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human PH and SEC7 domain-containing protein 1 protein (247-489AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PSD Antibody (CSB-PA018842LA01HU)，的标记方式是Non-conjugated。对于PSD Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA018842LB01HU PSD Antibody, HRP conjugated ELISA
    FITC CSB-PA018842LC01HU PSD Antibody, FITC conjugated
    Biotin CSB-PA018842LD01HU PSD Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling.
  • 基因功能参考文献：
    1. Arf GTPases are likely to be locally activated by EFA6 and in turn targeted to the Flemming body to complete cytokinesis. PMID: 26330566
    2. PSD expression might be a useful biomarker for epigenetic-based gastric cancer early diagnosis and may lead to the identification of new targets for pharmacological intervention. PMID: 25355626
    3. EFA6 is regulated by a negative feedback loop, which is mediated by an allosteric interaction of Arf6-GTP with a domain of EFA6 and monitors the activation of Arf1 and Arf6 differentially PMID: 25114232
    4. EFA6 participates in activation of Arf6 around the cleavage furrow during cytokinesis. PMID: 23603394
    5. Aberrant methylation of PSD occurs in UC-associated colorectal mucosa, enabling circumvention of Rac1 immune responses governing neutrophil chemotaxis and apoptosis, and plays a pivotal role in the mechanisms underlying UC-associated carcinogenesis. PMID: 22179719
    6. Both levels of accumulation of F-actin and apoptosis were significantly decreased in specimens from UC patients with PSD methylation compared to those without PSD methylation. PMID: 22002136
    7. Pleckstrin is a critical molecule for proinflammatory cytokine secretion in response to elevated advanced glycation end products (AGE) in diabetes. PMID: 17579087

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  • 亚细胞定位：
    Cell membrane. Cell projection, ruffle membrane. Cleavage furrow.
  • 蛋白家族：
    PSD family
  • 组织特异性：
    Isoform 2 is expressed in the brain.
  • 数据库链接：

    HGNC: 9507

    OMIM: 602327

    KEGG: hsa:5662

    STRING: 9606.ENSP00000020673

    UniGene: Hs.154658