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PSG1 Antibody

  • 货号：
    CSB-PA018849ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018849ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA018849ESR1HU at dilution of 1:100
    • Immunoprecipitating PSG1 in A549 whole cell lysate
      Lane 1: Rabbit control IgG instead of CSB-PA018849ESR1HU in A549 whole cell lysate. For western blotting, a HRP-conjµgated Protein G antibody was used as the secondary antibody (1/2000)
      Lane 2: CSB-PA018849ESR1HU (8µg) + A549 whole cell lysate (500µg)
      Lane 3: A549 whole cell lysate (10µg)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PSG1 Polyclonal antibody
  • Uniprot No.：
    P11464
  • 基因名：
    PSG1
  • 别名：
    B1G1 antibody; Carcinoembryonic antigen SG8 antibody; CD66 antigen-like family member F antibody; CD66f antibody; CD66f antigen antibody; CEA antibody; DHFRP2 antibody; Fetal liver non-specific cross-reactive antigen 1/2 antibody; FL-NCA-1/2 antibody; PBG 1 antibody; PBG1 antibody; Pregnancy specific B 1 glycoprotein antibody; Pregnancy specific beta 1 glycoprotein 1 antibody; Pregnancy specific beta 1 glycoprotein 2 antibody; Pregnancy specific beta 1 glycoprotein 7 antibody; Pregnancy specific beta 1 glycoprotein 8 antibody; Pregnancy specific beta 1 glycoprotein antibody; Pregnancy specific beta 1 glycoprotein C/D antibody; Pregnancy-specific beta-1 glycoprotein C/D antibody; Pregnancy-specific beta-1-glycoprotein 1 antibody; Pregnancy-specific glycoprotein 1 antibody; PS beta C/D antibody; PS-beta-C/D antibody; PS-beta-G-1 antibody; PSBG 1 antibody; PSBG 2 antibody; PSBG-1 antibody; PSBG1 antibody; PSBG2 antibody; PSG 1 antibody; PSG 2 antibody; PSG 8 antibody; PSG 95 antibody; PSG IIA d antibody; PSG1 antibody; PSG1_HUMAN antibody; PSG2 antibody; PSG8 antibody; PSG95 antibody; PSGGA antibody; PSGGB antibody; PSGIIA a antibody; PSGIIA antibody; PSGIIA b antibody; PSGIIA c antibody; SP 1 antibody; SP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Pregnancy-specific beta-1-glycoprotein 1 protein (180-419AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IP
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Inhibiting PSG1 can effectively reduce chemoresistance via a transforming growth factor-beta (TGF-beta)-related pathway in ER-negative breast cancer cells. PMID: 27653744
    2. PSG stimulated IDO activity under the conditions of induction of the monocytes by interferon-gamma. PMID: 27595833
    3. Under conditions of directed induction of phenotypic changes in CD4(+) lymphocytes to regulatory T cells (Treg), pregnancy-specific at high concentrations (10 and 100 mug/mL) increased FOXP3 expression. The evaluation of the spontaneous expression level of FOXP3 mRNA showed that pregnancy-specific beta1-glycoprotein (1 and 100 mug/mL) stimulated the expression of this factor in mononuclear cells and isolated CD4(+) lym... PMID: 27817017
    4. results identify a non-placental site of PSG expression in the gut and associated tumors, with implications for determining whether PSGs have a role in tumor progression, and utility as tumor biomarkers. PMID: 26926266
    5. the presence of GAGs on the surface of endothelial cells was required for the ability of PSG1 to induce tube formation PMID: 21193412
    6. The aspartic acid at position 95 is not required for PSG1 activity but the amino acids implicated in the formation of a salt bridge within the N-domain are essential. PMID: 20335639
    7. first trimester maternal serum marker of small-for-gestational age and preterm delivery PMID: 19911417
    8. Human PSG1a induces alternative activation in human & mouse monocytes & suppresses the accessory-cell-dependent T-cell proliferation. PSG1a contributes to immunomodulation during pregnancy, with opposite effects on maternal innate & adaptative systems. PMID: 12223519
    9. The differential expression of HLA-E and PSG1 in the sperm of fertile and infertile men is discussed. PMID: 18987160

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Immunoglobulin superfamily, CEA family
  • 数据库链接：

    HGNC: 9514

    OMIM: 176390

    KEGG: hsa:5669

    STRING: 9606.ENSP00000244296

    UniGene: Hs.709192