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PSMB9 Antibody

  • 货号：
    CSB-PA018887LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Raji whole cell lysate, HepG2 whole cell lysate, K562 whole cell lysate
      All lanes: PSMB9 antibody at 10µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 24, 23 kDa
      Observed band size: 24 kDa
    • IHC image of CSB-PA018887LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA018887LA01HU diluted at 1:400 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PSMB9 Polyclonal antibody
  • Uniprot No.：
    P28065
  • 基因名：
    PSMB9
  • 别名：
    Beta1i antibody; Large multifunctional peptidase 2 antibody; Large multifunctional protease 2 antibody; LMP 2 antibody; LMP2 antibody; Low molecular mass protein 2 antibody; Macropain chain 7 antibody; MGC70470 antibody; Multicatalytic endopeptidase complex chain 7 antibody; OTTHUMP00000062982 antibody; Proteasome (prosome macropain) subunit beta type 9 antibody; proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) antibody; Proteasome beta 9 subunit antibody; Proteasome catalytic subunit 1i antibody; Proteasome chain 7 antibody; Proteasome related gene 2 antibody; Proteasome subunit beta 6i antibody; Proteasome subunit beta type 9 antibody; Proteasome subunit beta type-9 antibody; Proteasome subunit beta-1i antibody; PSB9_HUMAN antibody; PSMB 9 antibody; PSMB6i antibody; PSMB9 antibody; Really interesting new gene 12 protein antibody; RING 12 antibody; RING12 antibody; RING12 protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Proteasome subunit beta type-9 protein (21-219AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PSMB9 Antibody (CSB-PA018887LA01HU)，的标记方式是Non-conjugated。对于PSMB9 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA018887LB01HU PSMB9 Antibody, HRP conjugated ELISA
    FITC CSB-PA018887LC01HU PSMB9 Antibody, FITC conjugated
    Biotin CSB-PA018887LD01HU PSMB9 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.
  • 基因功能参考文献：
    1. Defective PSMB9/beta1i expression is likely to be one of the risk factors for the development of human uterine neoplasm. PMID: 28482675
    2. single nucleotide polymorphism in PSMB9 are associated with hand dermatitis PMID: 27258892
    3. Chinese females carrying the rs17587-G/G genotype in PSMB9 may increase a higher risk for Parkinson's disease. PMID: 27098790
    4. The TAP1-rs1135216 and PSMB9-rs17587 variants are significantly associated with vitiligo, and even one copy of these mutant alleles can influence the risk among Saudis. PMID: 25548428
    5. study found prevalence of LMP2-AA genotype was higher in acute myeolid leukemia (AML) patients while it was significantly lower in multiple myeloma (MM) cases than in the control subjects; results suggestLMP2 polymorphisms could play a role in the development of AML and MM PMID: 24377540
    6. Data indicate that the codon 60 Arg/His polymorphism does not significantly alter the expression and activity of beta1i among the cell lines tested and clinical samples from colon and pancreatic cancer. PMID: 24040045
    7. functional variants in PSMB9 may contribute to melanoma susceptibility. PMID: 23360169
    8. LMP2 has a role as a tumor-suppressor and may have a role in uterine leiomyosarcoma therapy PMID: 22355695
    9. Genetic polymorphisms of rs17587 of PSMB9 appeared to be associated with rheumatoid arthritis in ethnic Han Chinese from Yunnan. PMID: 23568741
    10. study reports expression of LMP2 in patients with renal oncocytomas (RO) and eosinophilic variant of chromophobe renal cell carcinomas (CHRCC-EO); all CHRCC-EO cases (7 of 7) strongly showed nuclear LMP2 staining, as opposed to only 2 of 56 ROs; suggest its use as an aid in differential diagnosis of these neoplasias PMID: 22705098
    11. LMP2 expression in nasopharyngeal carcinoma is associated with poor prognosis. PMID: 22287277
    12. The polymorphic site is unique in the Chinese population of Han nationality at the LMP2 codon 60 loci (Arg60Cys), but a lack of association with lung cancer exists. PMID: 22261389
    13. LMP2 may negatively regulate LMS independently of its role in the proteasome. PMID: 22659265
    14. This is the first study to demonstrate that LMP2 variants can affect radiographic severity in ankylosing spondylitis. PMID: 22034108
    15. Data show that LMP2 60HH variant reduces the risk to develop MS amongst Italian HLA-A*02+ females. PMID: 20174631
    16. downregulation of expression in PBMC of chronic hepatitis B patients PMID: 20300807
    17. data show that the proteasomal ss1i subunit is dysregulated in peripheral white blood cells and in inflammatory infiltrates of minor salivary glands in patients with Sjogren's syndrome PMID: 19833746
    18. a high-frequency TAP1/LMP2 promoter polymorphism in human tumors PMID: 11788900
    19. caspase inhibition led to elevated levels of LMP2 and oxidized proteins; results suggest an age-related loss in capacity to carry out apoptosis might contribute to the observed accumulation of oxidized proteins during aging and in age-related diseases. PMID: 15284441
    20. These data suggest that LMP2 contributes to IkappaBalpha degradation and p50 generation, and that inhibition of LMP2 suppresses expression and activities of MMP-2 and MMP-9 by blocking the transfer of active NF-kappaB heterodimers into the nucleus. PMID: 16222703
    21. LMP2-associated proteasome is recruited to the entire sequence of ER target genes, implicating a role for the proteasome in both transcription initiation and elongation. PMID: 16957778
    22. These data reveal a novel "feed-forward" mechanism induced by NF-kappaB which ensures that acutely synthesized IRF-1 operates in concert with NF-kappaB to amplify the immunoproteasome and antigen-processing functions of CD40. PMID: 18694960
    23. Downregulation of LMP2 is associated with acute myeloid leukaemic blasts. PMID: 19148137
    24. Obtained data suggest the LMP2 and PSMA6 gene polymorphism significance as the risk factors of essential hypertension in adolescents. PMID: 19526842

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Peptidase T1B family
  • 数据库链接：

    HGNC: 9546

    OMIM: 177045

    KEGG: hsa:5698

    STRING: 9606.ENSP00000363993

    UniGene: Hs.654585