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PSMC2 Antibody

  • 货号：
    CSB-PA134529
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA134529(PSMC2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA134529(PSMC2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: 231 cells, Jurkat cells, mouse liver tissue, 293T cells, hela cells, Primary antibody: CSB-PA134529(PSMC2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他：

产品详情

  • Uniprot No.：
    P35998
  • 基因名：
    PSMC2
  • 别名：
    26S protease complex antibody; 26S protease regulatory subunit 7 antibody; 26S proteasome AAA-ATPase subunit RPT1 antibody; mammalian suppressor of sgv-1 of yeast antibody; MSS1 antibody; Nbla10058 antibody; protease 26S subunit 7 antibody; Proteasome 19S S7 antibody; proteasome 26S ATPase subunit 2 antibody; Proteasome 26S subunit ATPase 2 antibody; Proteasome 26S subunit ATPase 2 antibody; Protein MSS1 antibody; PRS7_HUMAN antibody; PSMC2 antibody; putative protein product of Nbla10058 antibody; S7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human PSMC2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
  • 基因功能参考文献：
    1. the finding of this study provided the new insight into the mechanism how PSMC2 contribute to osteosarcoma malignancy and further suggested PSMC2 might serve as an attractive potential therapeutic target drug target for osteosarcoma treatment. PMID: 27888613
    2. structural determinants for the binding of ubiquitin-like domains to 26s proteasome PMID: 12970176
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    AAA ATPase family
  • 数据库链接：

    HGNC: 9548

    OMIM: 154365

    KEGG: hsa:5701

    STRING: 9606.ENSP00000292644

    UniGene: Hs.437366