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PSMD2 Antibody

  • 货号：
    CSB-PA003870
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using PSMD2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q13200
  • 基因名：
    PSMD2
  • 别名：
    26S proteasome non-ATPase regulatory subunit 2 antibody; 26S proteasome regulatory subunit RPN1 antibody; 26S proteasome regulatory subunit S2 antibody; 26S proteasome subunit p97 antibody; 55.11 protein antibody; MGC14274 antibody; P97 antibody; Proteasome (prosome macropain) 26S subunit non ATPase 2 antibody; Proteasome 26S subunit; non-ATPase; 2 antibody; Proteasome 26S; subunit 2 antibody; Protein 55.11 antibody; Psmd2 antibody; PSMD2_HUMAN antibody; Rpn1 antibody; S2 antibody; TNFR associated protein 2 antibody; TRAP2 antibody; Tumor necrosis factor receptor associated protein 2 antibody; Tumor necrosis factor type 1 receptor-associated protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human PSMD2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.; Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
  • 基因功能参考文献：
    1. the high-resolution solution structure of the UBL domain of human UBLCP1 and its interaction with Rpn1 PMID: 23667555
    2. Results suggest that PSMD2 may be a good molecular target candidate. PMID: 21465578
    3. These data suggest that p97 recruits proteasomes to polytopic ER proteins, such as Insig-1, even before they are extracted from membranes. PMID: 19815544
    4. U87 glioblastoma cells transduced to express the epidermal growth factor receptor vIII (EGFRvIII) mutant do not respond toirrradiation with 26s proteasome inhibition. PMID: 18337449
    5. Data show that data provide a novel mechanism whereby CaMKII may regulate the proteasome in neurons to facilitate remodeling of synaptic connections through protein degradation. PMID: 19638347
    6. the 26S proteasome may provide a general predictive biomarker for radiotherapy outcome. PMID: 19881955

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  • 蛋白家族：
    Proteasome subunit S2 family
  • 组织特异性：
    Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.
  • 数据库链接：

    HGNC: 9559

    OMIM: 606223

    KEGG: hsa:5708

    STRING: 9606.ENSP00000310129

    UniGene: Hs.518464